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Scratching the surface: the processing of pain from deep tissues

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Sikandar, Shafaq ; Aasvang, Eske Kvanner ; Dickenson, Anthony H. / Scratching the surface : the processing of pain from deep tissues. In: Pain Management. 2016 ; Vol. 6, No. 2. pp. 95-102.

Bibtex

@article{f9b2d6540aef4634b2547ad326e02e01,
title = "Scratching the surface: the processing of pain from deep tissues",
abstract = "Although most pain research focuses on skin, muscles, joints and viscerae are major sources of pain. We discuss the mechanisms of deep pains arising from somatic and visceral structures and how this can lead to widespread manifestations and chronification. We include how both altered peripheral and central sensory neurotransmission lead to deep pain states and comment on key areas such as top-down modulation where little is known. It is vital that the clinical characterization of deep pain in patients is improved to allow for back translation to preclinical models so that the missing links can be ascertained. The contribution of deeper somatic and visceral tissues to various chronic pain syndromes is common but there is much we need to know.",
keywords = "Chronic Pain, Humans, Joints, Muscles, Nociception, Peripheral Nervous System, Viscera, Visceral Pain, Journal Article",
author = "Shafaq Sikandar and Aasvang, {Eske Kvanner} and Dickenson, {Anthony H}",
year = "2016",
month = apr,
doi = "10.2217/pmt.15.50",
language = "English",
volume = "6",
pages = "95--102",
journal = "Pain Management",
issn = "1758-1869",
publisher = "Future Medicine Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Scratching the surface

T2 - the processing of pain from deep tissues

AU - Sikandar, Shafaq

AU - Aasvang, Eske Kvanner

AU - Dickenson, Anthony H

PY - 2016/4

Y1 - 2016/4

N2 - Although most pain research focuses on skin, muscles, joints and viscerae are major sources of pain. We discuss the mechanisms of deep pains arising from somatic and visceral structures and how this can lead to widespread manifestations and chronification. We include how both altered peripheral and central sensory neurotransmission lead to deep pain states and comment on key areas such as top-down modulation where little is known. It is vital that the clinical characterization of deep pain in patients is improved to allow for back translation to preclinical models so that the missing links can be ascertained. The contribution of deeper somatic and visceral tissues to various chronic pain syndromes is common but there is much we need to know.

AB - Although most pain research focuses on skin, muscles, joints and viscerae are major sources of pain. We discuss the mechanisms of deep pains arising from somatic and visceral structures and how this can lead to widespread manifestations and chronification. We include how both altered peripheral and central sensory neurotransmission lead to deep pain states and comment on key areas such as top-down modulation where little is known. It is vital that the clinical characterization of deep pain in patients is improved to allow for back translation to preclinical models so that the missing links can be ascertained. The contribution of deeper somatic and visceral tissues to various chronic pain syndromes is common but there is much we need to know.

KW - Chronic Pain

KW - Humans

KW - Joints

KW - Muscles

KW - Nociception

KW - Peripheral Nervous System

KW - Viscera

KW - Visceral Pain

KW - Journal Article

U2 - 10.2217/pmt.15.50

DO - 10.2217/pmt.15.50

M3 - Journal article

C2 - 26974398

VL - 6

SP - 95

EP - 102

JO - Pain Management

JF - Pain Management

SN - 1758-1869

IS - 2

ER -

ID: 49812121