Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study

M Thomsen; B G Nordestgaard; Anne  Tybjærg-Hansen; Morten Dahl

doi:10.1111/j.1365-2796.2010.02308.x

Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study

M Thomsen, B G Nordestgaard, Anne Tybjærg-Hansen, Morten Dahl

10 Citations (Scopus)

Abstract

The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary disease (COPD) in the general population.

Original language	English
Journal	Journal of Internal Medicine
Volume	269
Issue number	3
Pages (from-to)	340-8
Number of pages	9
ISSN	0954-6820
DOIs	https://doi.org/10.1111/j.1365-2796.2010.02308.x
Publication status	Published - 2011

Keywords

Adult
Aged
Cohort Studies
Denmark
Female
Forced Expiratory Volume
Genetic Predisposition to Disease
Genetic Variation
Heterozygote
Humans
Lung
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive
Scavenger Receptors, Class A
Sex Factors
Vital Capacity

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10.1111/j.1365-2796.2010.02308.x

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title = "Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study",

abstract = "The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary disease (COPD) in the general population.",

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AU - Thomsen, M

AU - Nordestgaard, B G

AU - Tybjærg-Hansen, Anne

AU - Dahl, Morten

PY - 2011

Y1 - 2011

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AB - The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary disease (COPD) in the general population.

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Forced Expiratory Volume

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Heterozygote

KW - Humans

KW - Lung

KW - Male

KW - Middle Aged

KW - Pulmonary Disease, Chronic Obstructive

KW - Scavenger Receptors, Class A

KW - Sex Factors

KW - Vital Capacity

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DO - 10.1111/j.1365-2796.2010.02308.x

M3 - Journal article

C2 - 21077973

SN - 0954-6820

VL - 269

SP - 340

EP - 348

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 3

ER -

Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study

Abstract

Keywords

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