Abstract
In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been with the Pfizer-BioNTech (BTN162b2) or the Moderna (mRNA-1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our clinic received mRNA vaccinations according to the Danish roll-out vaccination plan. To monitor HCV infection, RNA was extracted from patient plasma and RNA sequencing was performed on the Illumina platform. In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID-19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid-nanoparticles and the half-life of these and mRNA vaccines in humans.
| Original language | English |
|---|---|
| Journal | APMIS - Journal of Pathology, Microbiology and Immunology |
| Volume | 131 |
| Issue number | 3 |
| Pages (from-to) | 128-132 |
| Number of pages | 5 |
| ISSN | 0903-4641 |
| DOIs | |
| Publication status | Published - Mar 2023 |
Keywords
- Antibodies, Viral
- COVID-19 Vaccines
- COVID-19/prevention & control
- Hepacivirus
- Hepatitis C
- Hepatitis C, Chronic
- Humans
- SARS-CoV-2/genetics
- Vaccination
- mRNA
- blood
- SARS-CoV-2
- vaccine
- Hepatitis C virus