Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic Population

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Plasma Proteomic Biomarkers Relating to Alzheimer’s Disease: A Meta-Analysis Based on Our Own Studies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence and Predictors of Prolonged Cognitive and Psychological Symptoms Following COVID-19 in the United States

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Brain Responses to Passive Sensory Stimulation Correlate With Intelligence

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Atrial fibrillation burden and cognitive decline in elderly patients undergoing continuous monitoring

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comparing a Single Clinician Versus a Multidisciplinary Consensus Conference Approach for Dementia Diagnostics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Comparison of the clinical impact of 2-[18F]FDG-PET and cerebrospinal fluid biomarkers in patients suspected of Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Neurodegeneration and axonal injury result in an increasing release of neurofilament light chain (NfL) into bodily fluids, including cerebrospinal fluid (CSF) and blood. Numerous studies have shown that NfL levels in CSF and blood are increased in neurodegenerative disorders and monitor neurodegeneration. Saliva is an easily accessible biofluid that could be utilized as a biofluid measurement of Alzheimer's disease (AD) biomarkers. In this study, for the first time, salivary NfL was measured and compared to plasma NfL in a consecutive cohort of patients referred to cognitive assessments. In two mixed memory clinic cohorts, saliva samples were taken from 152 patients, AD (n = 49), mild cognitive impairment (MCI) (n = 47), non-AD (n = 56), and also 17 healthy controls. In addition, 135 also had a matching plasma sample. All saliva and plasma samples were analyzed for NfL, and the association between saliva and plasma NfL and CSF levels of total tau (t-tau), phosphorylated tau (p-tau), and beta amyloid 1-42 (Aβ42) were investigated. In total, 162/169 had quantifiable levels of salivary NfL by single molecule array (Simoa). No statistically significant differences were found in salivary NfL concentration across the diagnostic groups, but as expected, significant increases were found for plasma NfL in dementia cases (P < 0.0001). There was no association between saliva and plasma NfL levels. Furthermore, saliva NfL did not correlate with CSF Aβ42, p-tau, or tau concentrations. In conclusion, NfL is detectable in saliva but does not reflect neurodegeneration in the brain.

Original languageEnglish
Article number659898
JournalFrontiers in Aging Neuroscience
Volume13
Pages (from-to)659898
ISSN1663-4365
DOIs
Publication statusPublished - 2021

Bibliographical note

Copyright © 2021 Gleerup, Sanna, Høgh, Simrén, Blennow, Zetterberg, Hasselbalch, Ashton and Simonsen.

ID: 68396141