RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC

Adam Christian Vilmar; J Garcia-Foncillas; M Huarriz; E Santoni-Rugiu; J B Sorensen

doi:10.1016/j.lungcan.2011.08.016

RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC

Adam Christian Vilmar, J Garcia-Foncillas, M Huarriz, E Santoni-Rugiu, J B Sorensen

Department of Pathology

45 Citations (Scopus)

Abstract

Customized chemotherapy is increasingly used in the management of patients with advanced non-small cell lung cancer (NSCLC). However, the most reliable methodology to determine biomarker status is neither fully elucidated nor agreed upon. Accordingly, we evaluated the predictive efficiency of qRT-PCR and immunohistochemical analysis (IHC) on excision cross complementation group 1 (ERCC1), breast cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III β-tubulin (TUBB3).

Original language	English
Journal	Lung Cancer
Volume	75
Issue number	3
Pages (from-to)	306-12
Number of pages	7
ISSN	0169-5002
DOIs	https://doi.org/10.1016/j.lungcan.2011.08.016
Publication status	Published - 2012

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10.1016/j.lungcan.2011.08.016

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title = "RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC",

abstract = "Customized chemotherapy is increasingly used in the management of patients with advanced non-small cell lung cancer (NSCLC). However, the most reliable methodology to determine biomarker status is neither fully elucidated nor agreed upon. Accordingly, we evaluated the predictive efficiency of qRT-PCR and immunohistochemical analysis (IHC) on excision cross complementation group 1 (ERCC1), breast cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III β-tubulin (TUBB3).",

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AU - Vilmar, Adam Christian

AU - Garcia-Foncillas, J

AU - Huarriz, M

AU - Santoni-Rugiu, E

AU - Sorensen, J B

PY - 2012

Y1 - 2012

N2 - Customized chemotherapy is increasingly used in the management of patients with advanced non-small cell lung cancer (NSCLC). However, the most reliable methodology to determine biomarker status is neither fully elucidated nor agreed upon. Accordingly, we evaluated the predictive efficiency of qRT-PCR and immunohistochemical analysis (IHC) on excision cross complementation group 1 (ERCC1), breast cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III β-tubulin (TUBB3).

AB - Customized chemotherapy is increasingly used in the management of patients with advanced non-small cell lung cancer (NSCLC). However, the most reliable methodology to determine biomarker status is neither fully elucidated nor agreed upon. Accordingly, we evaluated the predictive efficiency of qRT-PCR and immunohistochemical analysis (IHC) on excision cross complementation group 1 (ERCC1), breast cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III β-tubulin (TUBB3).

UR - https://www.scopus.com/pages/publications/84856577873

U2 - 10.1016/j.lungcan.2011.08.016

DO - 10.1016/j.lungcan.2011.08.016

M3 - Journal article

C2 - 21996087

SN - 0169-5002

VL - 75

SP - 306

EP - 312

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC

Abstract

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