Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE)

Helle Pappot; Christina Baeksted; Ann Knoop; Sandra A Mitchell; Aase Nissen; Christoffer Johansen

doi:10.1111/tbj.13204

Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE)

Helle Pappot, Christina Baeksted, Ann Knoop, Sandra A Mitchell, Aase Nissen, Christoffer Johansen

Department of Oncology

13 Citations (Scopus)

Abstract

The Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) was developed by the National Cancer Institute to capture patient self-reports of symptomatic toxicities during cancer treatment. The aim of this short communication is to describe the design of a national study, which examine the effect of using patients' electronic PRO-CTCAE reporting with real-time feedback to clinicians on treatment events for breast cancer patients receiving adjuvant chemotherapy. The study's end-points are defined as dose reduction, hospitalization, and febrile neutropenia. This is the first report on the impact of PRO-CTCAE in a national breast cancer population during chemotherapy treatment.

Original language	English
Journal	Breast
Volume	25
Issue number	2
Pages (from-to)	269-272
ISSN	0960-9776
DOIs	https://doi.org/10.1111/tbj.13204
Publication status	Published - 2019

Keywords

PRO-CTCAE
adjuvant chemotherapy
breast cancer
patient reported outcome
toxicity
Humans
Hospitalization
Neutropenia/chemically induced
Randomized Controlled Trials as Topic
Denmark
Female
Chemotherapy, Adjuvant/adverse effects
Breast Neoplasms/drug therapy
Patient Reported Outcome Measures

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Pappot, H., Baeksted, C., Knoop, A., Mitchell, S. A., Nissen, A., & Johansen, C. (2019). Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE). Breast, 25(2), 269-272. https://doi.org/10.1111/tbj.13204

Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE). / Pappot, Helle; Baeksted, Christina; Knoop, Ann et al.
In: Breast, Vol. 25, No. 2, 2019, p. 269-272.

Research output: Contribution to journal › Journal article › Research › peer-review

Pappot, H, Baeksted, C, Knoop, A, Mitchell, SA, Nissen, A & Johansen, C 2019, 'Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE)', Breast, vol. 25, no. 2, pp. 269-272. https://doi.org/10.1111/tbj.13204

Pappot H, Baeksted C, Knoop A, Mitchell SA, Nissen A, Johansen C. Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE). Breast. 2019;25(2):269-272. doi: 10.1111/tbj.13204

Pappot, Helle ; Baeksted, Christina ; Knoop, Ann et al. / Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE). In: Breast. 2019 ; Vol. 25, No. 2. pp. 269-272.

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abstract = "The Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) was developed by the National Cancer Institute to capture patient self-reports of symptomatic toxicities during cancer treatment. The aim of this short communication is to describe the design of a national study, which examine the effect of using patients' electronic PRO-CTCAE reporting with real-time feedback to clinicians on treatment events for breast cancer patients receiving adjuvant chemotherapy. The study's end-points are defined as dose reduction, hospitalization, and febrile neutropenia. This is the first report on the impact of PRO-CTCAE in a national breast cancer population during chemotherapy treatment.",

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Routine surveillance for symptomatic toxicities with real-time clinician reporting in Danish breast cancer patients-Organization and design of the first national, cluster randomized trial using the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE)

Abstract

Keywords

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