Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma

Nicolai C Sjö; Pia Foegh; Birgitte R Juhl; Hans-Olof Nilsson; Jan U Prause; Elisabeth Ralfkiaer; Torkel Wadström; Steffen Heegaard

doi:10.1016/j.ophtha.2006.09.020

Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma

Nicolai C Sjö, Pia Foegh, Birgitte R Juhl, Hans-Olof Nilsson, Jan U Prause, Elisabeth Ralfkiaer, Torkel Wadström, Steffen Heegaard

Department of Pathology

46 Citations (Scopus)

Abstract

OBJECTIVE: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated.

DESIGN: Retrospective noncomparative case series.

PARTICIPANTS: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls.

METHODS: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected.

MAIN OUTCOME MEASURES: Detection of H. pylori and patient characteristics.

RESULTS: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylori could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques.

CONCLUSIONS: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylori may take part in the development of conjunctival MALT lymphoma.

Original language	English
Journal	Ophthalmology
Volume	114
Issue number	1
Pages (from-to)	182-6
Number of pages	5
ISSN	0161-6420
DOIs	https://doi.org/10.1016/j.ophtha.2006.09.020
Publication status	Published - Jan 2007

Keywords

Adult
Aged
Aged, 80 and over
Conjunctival Neoplasms/microbiology
DNA, Bacterial/analysis
Female
Helicobacter Infections/microbiology
Helicobacter pylori/genetics
Humans
Immunoenzyme Techniques
Lymphoma, B-Cell, Marginal Zone/microbiology
Male
Middle Aged
Polymerase Chain Reaction
Retrospective Studies

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10.1016/j.ophtha.2006.09.020

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@article{e5fc6d220c264ce09e193669270e53eb,

title = "Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma",

abstract = "OBJECTIVE: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated.DESIGN: Retrospective noncomparative case series.PARTICIPANTS: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls.METHODS: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected.MAIN OUTCOME MEASURES: Detection of H. pylori and patient characteristics.RESULTS: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylori could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques.CONCLUSIONS: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylori may take part in the development of conjunctival MALT lymphoma.",

keywords = "Adult, Aged, Aged, 80 and over, Conjunctival Neoplasms/microbiology, DNA, Bacterial/analysis, Female, Helicobacter Infections/microbiology, Helicobacter pylori/genetics, Humans, Immunoenzyme Techniques, Lymphoma, B-Cell, Marginal Zone/microbiology, Male, Middle Aged, Polymerase Chain Reaction, Retrospective Studies",

author = "Sj{\"o}, \{Nicolai C\} and Pia Foegh and Juhl, \{Birgitte R\} and Hans-Olof Nilsson and Prause, \{Jan U\} and Elisabeth Ralfkiaer and Torkel Wadstr{\"o}m and Steffen Heegaard",

year = "2007",

month = jan,

doi = "10.1016/j.ophtha.2006.09.020",

language = "English",

volume = "114",

pages = "182--6",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma

AU - Sjö, Nicolai C

AU - Foegh, Pia

AU - Juhl, Birgitte R

AU - Nilsson, Hans-Olof

AU - Prause, Jan U

AU - Ralfkiaer, Elisabeth

AU - Wadström, Torkel

AU - Heegaard, Steffen

PY - 2007/1

Y1 - 2007/1

N2 - OBJECTIVE: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated.DESIGN: Retrospective noncomparative case series.PARTICIPANTS: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls.METHODS: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected.MAIN OUTCOME MEASURES: Detection of H. pylori and patient characteristics.RESULTS: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylori could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques.CONCLUSIONS: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylori may take part in the development of conjunctival MALT lymphoma.

AB - OBJECTIVE: Conjunctiva-associated lymphoid tissue is the conjunctival equivalent to mucosa-associated lymphoid tissue (MALT). Mucosa-associated lymphoid tissue lymphoma has been shown to be associated with Helicobacter pylori. In this study, the prevalence and possible role of H. pylori infection in conjunctival MALT lymphoma were evaluated.DESIGN: Retrospective noncomparative case series.PARTICIPANTS: Thirteen cases of conjunctival MALT lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls.METHODS: The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected.MAIN OUTCOME MEASURES: Detection of H. pylori and patient characteristics.RESULTS: The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylori could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques.CONCLUSIONS: An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylori may take part in the development of conjunctival MALT lymphoma.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Conjunctival Neoplasms/microbiology

KW - DNA, Bacterial/analysis

KW - Female

KW - Helicobacter Infections/microbiology

KW - Helicobacter pylori/genetics

KW - Humans

KW - Immunoenzyme Techniques

KW - Lymphoma, B-Cell, Marginal Zone/microbiology

KW - Male

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Retrospective Studies

UR - https://www.scopus.com/pages/publications/33845808774

U2 - 10.1016/j.ophtha.2006.09.020

DO - 10.1016/j.ophtha.2006.09.020

M3 - Journal article

C2 - 17198854

SN - 0161-6420

VL - 114

SP - 182

EP - 186

JO - Ophthalmology

JF - Ophthalmology

IS - 1

ER -

Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma

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Keywords

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