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Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies

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Harvard

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care) 2022, 'Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies', Annals of Intensive Care, vol. 12, no. 1, 8. https://doi.org/10.1186/s13613-022-00983-0

APA

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care) (2022). Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies. Annals of Intensive Care, 12(1), [8]. https://doi.org/10.1186/s13613-022-00983-0

CBE

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care). 2022. Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies. Annals of Intensive Care. 12(1):Article 8. https://doi.org/10.1186/s13613-022-00983-0

MLA

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care). "Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies". Annals of Intensive Care. 2022. 12(1). https://doi.org/10.1186/s13613-022-00983-0

Vancouver

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care). Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies. Annals of Intensive Care. 2022 Dec;12(1). 8. https://doi.org/10.1186/s13613-022-00983-0

Author

the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care). / Role of extracorporeal membrane oxygenation in pediatric cancer patients : a systematic review and meta-analysis of observational studies. In: Annals of Intensive Care. 2022 ; Vol. 12, No. 1.

Bibtex

@article{e8dd8cdcb9cb4b1fab2011de6caab6da,
title = "Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies",
abstract = "Background: The use of extracorporeal membrane oxygenation (ECMO) in pediatric patients with underlying malignancies remains controversial. However, in an era in which the survival rates for children with malignancies have increased significantly and several recent reports have demonstrated effective ECMO use in children with cancer, we aimed to estimate the outcome and complications of ECMO treatment in these children. Methods: We searched MEDLINE, Embase and CINAHL databases for studies on the use ECMO in pediatric patients with an underlying malignancy from inception to September 2020. This review was conducted in adherence to Preferred Reporting Items for Systematic Review and Meta-Analysis statement. Study eligibility was independently assessed by two authors and disagreements resolved by a third author. Included studies were evaluated for quality using the Newcastle–Ottawa Scale (NOS). Random effects meta-analyses (DerSimonian and Laird) were performed. The primary outcomes were mortality during ECMO or hospital mortality. Results: Thirteen retrospective, observational cohort studies were included, most of moderate quality (625 patients). The commonest indication for ECMO was severe respiratory failure (92%). Pooled mortality during ECMO was 55% (95% confidence interval [CI], 47–63%) and pooled hospital mortality was 60% (95% CI 54–67%). Although heterogeneity among the included studies was low, confidence intervals were large. In addition, the majority of the data were derived from registries with overlapping patients which were excluded for the meta-analyses to prevent resampling of the same participants across the included studies. Finally, there was a lack of consistent complications reporting among the studies. Conclusion: Significantly higher mortalities than in general PICU patients was reported with the use of ECMO in children with malignancies. Although these results need to be interpreted with caution due to the lack of granular data, they suggest that ECMO appears to represents a viable rescue option for selected patients with underlying malignancies. There is an urgent need for additional data to define patients for whom ECMO may provide benefit or harm.",
keywords = "Cancer, Extracorporeal membrane oxygenation, Meta-analysis, Outcomes, Pediatric intensive care unit, Systematic review",
author = "Valerie Slooff and Rianne Hoogendoorn and Nielsen, {Jeppe Sylvest Angaard} and John Pappachan and Angela Amigoni and Fabio Caramelli and Omer Aziz and Enno Wildschut and Sascha Verbruggen and Roman Crazzolara and Christian Dohna-Schwake and Jenny Potratz and Jef Willems and Judit Llevadias and Andrea Moscatelli and Alessia Montaguti and Gabriella Bottari and {Di Nardo}, Matteo and Luregn Schlapbach and {W{\"o}sten-van Asperen}, Roelie and {the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care)}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1186/s13613-022-00983-0",
language = "English",
volume = "12",
journal = "Annals of Intensive Care",
issn = "2110-5820",
publisher = "SpringerOpen",
number = "1",

}

RIS

TY - JOUR

T1 - Role of extracorporeal membrane oxygenation in pediatric cancer patients

T2 - a systematic review and meta-analysis of observational studies

AU - Slooff, Valerie

AU - Hoogendoorn, Rianne

AU - Nielsen, Jeppe Sylvest Angaard

AU - Pappachan, John

AU - Amigoni, Angela

AU - Caramelli, Fabio

AU - Aziz, Omer

AU - Wildschut, Enno

AU - Verbruggen, Sascha

AU - Crazzolara, Roman

AU - Dohna-Schwake, Christian

AU - Potratz, Jenny

AU - Willems, Jef

AU - Llevadias, Judit

AU - Moscatelli, Andrea

AU - Montaguti, Alessia

AU - Bottari, Gabriella

AU - Di Nardo, Matteo

AU - Schlapbach, Luregn

AU - Wösten-van Asperen, Roelie

AU - the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric Neonatal Intensive Care)

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Background: The use of extracorporeal membrane oxygenation (ECMO) in pediatric patients with underlying malignancies remains controversial. However, in an era in which the survival rates for children with malignancies have increased significantly and several recent reports have demonstrated effective ECMO use in children with cancer, we aimed to estimate the outcome and complications of ECMO treatment in these children. Methods: We searched MEDLINE, Embase and CINAHL databases for studies on the use ECMO in pediatric patients with an underlying malignancy from inception to September 2020. This review was conducted in adherence to Preferred Reporting Items for Systematic Review and Meta-Analysis statement. Study eligibility was independently assessed by two authors and disagreements resolved by a third author. Included studies were evaluated for quality using the Newcastle–Ottawa Scale (NOS). Random effects meta-analyses (DerSimonian and Laird) were performed. The primary outcomes were mortality during ECMO or hospital mortality. Results: Thirteen retrospective, observational cohort studies were included, most of moderate quality (625 patients). The commonest indication for ECMO was severe respiratory failure (92%). Pooled mortality during ECMO was 55% (95% confidence interval [CI], 47–63%) and pooled hospital mortality was 60% (95% CI 54–67%). Although heterogeneity among the included studies was low, confidence intervals were large. In addition, the majority of the data were derived from registries with overlapping patients which were excluded for the meta-analyses to prevent resampling of the same participants across the included studies. Finally, there was a lack of consistent complications reporting among the studies. Conclusion: Significantly higher mortalities than in general PICU patients was reported with the use of ECMO in children with malignancies. Although these results need to be interpreted with caution due to the lack of granular data, they suggest that ECMO appears to represents a viable rescue option for selected patients with underlying malignancies. There is an urgent need for additional data to define patients for whom ECMO may provide benefit or harm.

AB - Background: The use of extracorporeal membrane oxygenation (ECMO) in pediatric patients with underlying malignancies remains controversial. However, in an era in which the survival rates for children with malignancies have increased significantly and several recent reports have demonstrated effective ECMO use in children with cancer, we aimed to estimate the outcome and complications of ECMO treatment in these children. Methods: We searched MEDLINE, Embase and CINAHL databases for studies on the use ECMO in pediatric patients with an underlying malignancy from inception to September 2020. This review was conducted in adherence to Preferred Reporting Items for Systematic Review and Meta-Analysis statement. Study eligibility was independently assessed by two authors and disagreements resolved by a third author. Included studies were evaluated for quality using the Newcastle–Ottawa Scale (NOS). Random effects meta-analyses (DerSimonian and Laird) were performed. The primary outcomes were mortality during ECMO or hospital mortality. Results: Thirteen retrospective, observational cohort studies were included, most of moderate quality (625 patients). The commonest indication for ECMO was severe respiratory failure (92%). Pooled mortality during ECMO was 55% (95% confidence interval [CI], 47–63%) and pooled hospital mortality was 60% (95% CI 54–67%). Although heterogeneity among the included studies was low, confidence intervals were large. In addition, the majority of the data were derived from registries with overlapping patients which were excluded for the meta-analyses to prevent resampling of the same participants across the included studies. Finally, there was a lack of consistent complications reporting among the studies. Conclusion: Significantly higher mortalities than in general PICU patients was reported with the use of ECMO in children with malignancies. Although these results need to be interpreted with caution due to the lack of granular data, they suggest that ECMO appears to represents a viable rescue option for selected patients with underlying malignancies. There is an urgent need for additional data to define patients for whom ECMO may provide benefit or harm.

KW - Cancer

KW - Extracorporeal membrane oxygenation

KW - Meta-analysis

KW - Outcomes

KW - Pediatric intensive care unit

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=85124841675&partnerID=8YFLogxK

U2 - 10.1186/s13613-022-00983-0

DO - 10.1186/s13613-022-00983-0

M3 - Review

C2 - 35092500

AN - SCOPUS:85124841675

VL - 12

JO - Annals of Intensive Care

JF - Annals of Intensive Care

SN - 2110-5820

IS - 1

M1 - 8

ER -

ID: 79410054