Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat

A Gozalov; I Jansen-Olesen; D Klaerke; J Olesen

doi:10.1111/j.1468-2982.2007.01409.x

Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat

A Gozalov, I Jansen-Olesen, D Klaerke, J Olesen

35 Citations (Scopus)

Abstract

Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are potent vasodilators that have been shown to induce headache in migraine patients. Their antagonists are effective in the treatment of migraine attacks. In the present study, we hypothesize that vasodilation induced by the NO donor glyceryltrinitrate (GTN) or by CGRP is partially mediated via large conductance calcium-activated potassium (BK(Ca)) channels. The effects of the BK(Ca) channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined. Iberiotoxin significantly attenuated GTN-induced dural and pial artery dilation in vivo and in vitro, but had no effect on vasodilation induced by CGRP and TES. Our results show that GTN- but not CGRP-induced dural and pial vasodilation involves opening of BK(Ca) channels in rat.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	27
Issue number	10
Pages (from-to)	1120-7
Number of pages	8
ISSN	0333-1024
DOIs	https://doi.org/10.1111/j.1468-2982.2007.01409.x
Publication status	Published - Oct 2007
Externally published	Yes

Keywords

Animals
Calcitonin Gene-Related Peptide/pharmacology
Cerebral Arteries/drug effects
Dura Mater/blood supply
Head/blood supply
Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors
Laser-Doppler Flowmetry
Male
Meningeal Arteries/drug effects
Nitric Oxide/metabolism
Nitroglycerin/pharmacology
Peptides/pharmacology
Pia Mater/blood supply
Rats
Rats, Sprague-Dawley
Transcutaneous Electric Nerve Stimulation
Vasodilation/drug effects
Vasodilator Agents/pharmacology

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10.1111/j.1468-2982.2007.01409.x

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title = "Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat",

abstract = "Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are potent vasodilators that have been shown to induce headache in migraine patients. Their antagonists are effective in the treatment of migraine attacks. In the present study, we hypothesize that vasodilation induced by the NO donor glyceryltrinitrate (GTN) or by CGRP is partially mediated via large conductance calcium-activated potassium (BK(Ca)) channels. The effects of the BK(Ca) channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined. Iberiotoxin significantly attenuated GTN-induced dural and pial artery dilation in vivo and in vitro, but had no effect on vasodilation induced by CGRP and TES. Our results show that GTN- but not CGRP-induced dural and pial vasodilation involves opening of BK(Ca) channels in rat.",

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author = "A Gozalov and I Jansen-Olesen and D Klaerke and J Olesen",

year = "2007",

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doi = "10.1111/j.1468-2982.2007.01409.x",

language = "English",

volume = "27",

pages = "1120--7",

journal = "Cephalalgia : an international journal of headache",

issn = "0333-1024",

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T1 - Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat

AU - Gozalov, A

AU - Jansen-Olesen, I

AU - Klaerke, D

AU - Olesen, J

PY - 2007/10

Y1 - 2007/10

N2 - Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are potent vasodilators that have been shown to induce headache in migraine patients. Their antagonists are effective in the treatment of migraine attacks. In the present study, we hypothesize that vasodilation induced by the NO donor glyceryltrinitrate (GTN) or by CGRP is partially mediated via large conductance calcium-activated potassium (BK(Ca)) channels. The effects of the BK(Ca) channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined. Iberiotoxin significantly attenuated GTN-induced dural and pial artery dilation in vivo and in vitro, but had no effect on vasodilation induced by CGRP and TES. Our results show that GTN- but not CGRP-induced dural and pial vasodilation involves opening of BK(Ca) channels in rat.

AB - Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are potent vasodilators that have been shown to induce headache in migraine patients. Their antagonists are effective in the treatment of migraine attacks. In the present study, we hypothesize that vasodilation induced by the NO donor glyceryltrinitrate (GTN) or by CGRP is partially mediated via large conductance calcium-activated potassium (BK(Ca)) channels. The effects of the BK(Ca) channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined. Iberiotoxin significantly attenuated GTN-induced dural and pial artery dilation in vivo and in vitro, but had no effect on vasodilation induced by CGRP and TES. Our results show that GTN- but not CGRP-induced dural and pial vasodilation involves opening of BK(Ca) channels in rat.

KW - Animals

KW - Calcitonin Gene-Related Peptide/pharmacology

KW - Cerebral Arteries/drug effects

KW - Dura Mater/blood supply

KW - Head/blood supply

KW - Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors

KW - Laser-Doppler Flowmetry

KW - Male

KW - Meningeal Arteries/drug effects

KW - Nitric Oxide/metabolism

KW - Nitroglycerin/pharmacology

KW - Peptides/pharmacology

KW - Pia Mater/blood supply

KW - Rats

KW - Rats, Sprague-Dawley

KW - Transcutaneous Electric Nerve Stimulation

KW - Vasodilation/drug effects

KW - Vasodilator Agents/pharmacology

UR - https://www.scopus.com/pages/publications/34748861020

U2 - 10.1111/j.1468-2982.2007.01409.x

DO - 10.1111/j.1468-2982.2007.01409.x

M3 - Journal article

C2 - 17714519

SN - 0333-1024

VL - 27

SP - 1120

EP - 1127

JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

IS - 10

ER -

Role of BK(Ca) channels in cephalic vasodilation induced by CGRP, NO and transcranial electrical stimulation in the rat

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Keywords

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