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RNA assemblages orchestrate complex cellular processes

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Nielsen, Finn Cilius ; Hansen, Heidi Theil ; Christiansen, Jan. / RNA assemblages orchestrate complex cellular processes. In: BioEssays. 2016 ; Vol. 38, No. 7. pp. 674-81.

Bibtex

@article{cfed3b4e7fe4475e9aaf3593a8e3b898,
title = "RNA assemblages orchestrate complex cellular processes",
abstract = "Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed in the present review.",
keywords = "Journal Article",
author = "Nielsen, {Finn Cilius} and Hansen, {Heidi Theil} and Jan Christiansen",
note = "2016 The Authors BioEssays Published by WILEY Periodicals, Inc.",
year = "2016",
month = "7",
doi = "10.1002/bies.201500175",
language = "English",
volume = "38",
pages = "674--81",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John/Wiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - RNA assemblages orchestrate complex cellular processes

AU - Nielsen, Finn Cilius

AU - Hansen, Heidi Theil

AU - Christiansen, Jan

N1 - 2016 The Authors BioEssays Published by WILEY Periodicals, Inc.

PY - 2016/7

Y1 - 2016/7

N2 - Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed in the present review.

AB - Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid droplets via liquid-liquid phase separation, and in this way create cytoplasmic assemblages of functionally related mRNAs. In a recent iCLIP study, we showed that the Drosophila RNA-binding protein Imp, which exhibits a C-terminal low-complexity sequence, increases the formation of F-actin by binding to 3' untranslated regions of mRNAs encoding components participating in F-actin biogenesis. We hypothesize that phase transition is a mechanism the cell employs to increase the local mRNA concentration considerably, and in this way synchronize protein production in cytoplasmic territories, as discussed in the present review.

KW - Journal Article

U2 - 10.1002/bies.201500175

DO - 10.1002/bies.201500175

M3 - Journal article

VL - 38

SP - 674

EP - 681

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 7

ER -

ID: 49833124