Risk of uncommon cancers in patients with psoriasis: a Danish nationwide cohort study

P Jensen; A Egeberg; G Gislason; J P Thyssen; L Skov

doi:10.1111/jdv.14610

Risk of uncommon cancers in patients with psoriasis: a Danish nationwide cohort study

P Jensen^*, A Egeberg, G Gislason, J P Thyssen, L Skov

^*Corresponding author for this work

9 Citations (Scopus)

Abstract

BACKGROUND: Cancer-associated mortality is increased in psoriasis. However, little is known about the risk of less common cancers.

OBJECTIVE: We aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study.

METHODS: Between 1 January 2008 and 31 December 2012, we identified all Danish patients with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100.000 persons in Denmark. The primary endpoint was the occurrence of a diagnosis of cancer.

RESULTS: We included 4 361 869 individuals. Of these, 58 138 were classified as having psoriasis. After adjusting for age, sex, socio-economic status and healthcare consumption, we found significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32-10.62], P < 0.0001) in patients with psoriasis on systemic treatment.

CONCLUSION: We provide further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis.

Original language	English
Journal	Journal of the European Academy of Dermatology and Venereology : JEADV
Volume	32
Issue number	4
Pages (from-to)	601-605
ISSN	0926-9959
DOIs	https://doi.org/10.1111/jdv.14610
Publication status	Published - Apr 2018

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Journal Article

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10.1111/jdv.14610

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title = "Risk of uncommon cancers in patients with psoriasis: a Danish nationwide cohort study",

abstract = "BACKGROUND: Cancer-associated mortality is increased in psoriasis. However, little is known about the risk of less common cancers.OBJECTIVE: We aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study.METHODS: Between 1 January 2008 and 31 December 2012, we identified all Danish patients with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100.000 persons in Denmark. The primary endpoint was the occurrence of a diagnosis of cancer.RESULTS: We included 4 361 869 individuals. Of these, 58 138 were classified as having psoriasis. After adjusting for age, sex, socio-economic status and healthcare consumption, we found significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32-10.62], P < 0.0001) in patients with psoriasis on systemic treatment.CONCLUSION: We provide further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis.",

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author = "P Jensen and A Egeberg and G Gislason and Thyssen, {J P} and L Skov",

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year = "2018",

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doi = "10.1111/jdv.14610",

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pages = "601--605",

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T1 - Risk of uncommon cancers in patients with psoriasis

T2 - a Danish nationwide cohort study

AU - Jensen, P

AU - Egeberg, A

AU - Gislason, G

AU - Thyssen, J P

AU - Skov, L

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N2 - BACKGROUND: Cancer-associated mortality is increased in psoriasis. However, little is known about the risk of less common cancers.OBJECTIVE: We aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study.METHODS: Between 1 January 2008 and 31 December 2012, we identified all Danish patients with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100.000 persons in Denmark. The primary endpoint was the occurrence of a diagnosis of cancer.RESULTS: We included 4 361 869 individuals. Of these, 58 138 were classified as having psoriasis. After adjusting for age, sex, socio-economic status and healthcare consumption, we found significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32-10.62], P < 0.0001) in patients with psoriasis on systemic treatment.CONCLUSION: We provide further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis.

AB - BACKGROUND: Cancer-associated mortality is increased in psoriasis. However, little is known about the risk of less common cancers.OBJECTIVE: We aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study.METHODS: Between 1 January 2008 and 31 December 2012, we identified all Danish patients with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100.000 persons in Denmark. The primary endpoint was the occurrence of a diagnosis of cancer.RESULTS: We included 4 361 869 individuals. Of these, 58 138 were classified as having psoriasis. After adjusting for age, sex, socio-economic status and healthcare consumption, we found significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32-10.62], P < 0.0001) in patients with psoriasis on systemic treatment.CONCLUSION: We provide further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis.

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Risk of uncommon cancers in patients with psoriasis: a Danish nationwide cohort study

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