Risk of triple-class virological failure in children with HIV: a retrospective cohort study

Hannah Castro; Ali Judd; Diana M Gibb; Karina Butler; Rebecca K Lodwick; Ard van Sighem; Jose T Ramos; Josiane Warsawski; Claire Thorne; Antoni Noguera-Julian; Niels Obel; Dominique Costagliola; Pat A Tookey; Céline Colin; Jesper Kjaer; Jesper Grarup; Genevieve Chene; Andrew Phillips; Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

doi:10.1016/S0140-6736(11)60208-0

Risk of triple-class virological failure in children with HIV: a retrospective cohort study

Hannah Castro, Ali Judd, Diana M Gibb, Karina Butler, Rebecca K Lodwick, Ard van Sighem, Jose T Ramos, Josiane Warsawski, Claire Thorne, Antoni Noguera-Julian, Niels Obel, Dominique Costagliola, Pat A Tookey, Céline Colin, Jesper Kjaer, Jesper Grarup, Genevieve Chene, Andrew Phillips, Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

99 Citations (Scopus)

Abstract

In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

Original language	English
Journal	Lancet
Volume	377
Issue number	9777
Pages (from-to)	1580-7
Number of pages	8
ISSN	0140-6736
DOIs	https://doi.org/10.1016/S0140-6736(11)60208-0
Publication status	Published - 7 May 2011

Keywords

Adolescent
Anti-Retroviral Agents
Child
Child, Preschool
Cohort Studies
Female
HIV Infections
Humans
Infant
Infectious Disease Transmission, Vertical
Kaplan-Meier Estimate
Male
Proportional Hazards Models
Retrospective Studies
Risk
Treatment Failure
Viral Load

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Castro, H., Judd, A., Gibb, D. M., Butler, K., Lodwick, R. K., van Sighem, A., Ramos, J. T., Warsawski, J., Thorne, C., Noguera-Julian, A., Obel, N., Costagliola, D., Tookey, P. A., Colin, C., Kjaer, J., Grarup, J., Chene, G., Phillips, A., & Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) (2011). Risk of triple-class virological failure in children with HIV: a retrospective cohort study. Lancet, 377(9777), 1580-7. https://doi.org/10.1016/S0140-6736(11)60208-0

Castro, H, Judd, A, Gibb, DM, Butler, K, Lodwick, RK, van Sighem, A, Ramos, JT, Warsawski, J, Thorne, C, Noguera-Julian, A, Obel, N, Costagliola, D, Tookey, PA, Colin, C, Kjaer, J, Grarup, J, Chene, G, Phillips, A & Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) 2011, 'Risk of triple-class virological failure in children with HIV: a retrospective cohort study', Lancet, vol. 377, no. 9777, pp. 1580-7. https://doi.org/10.1016/S0140-6736(11)60208-0

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AU - van Sighem, Ard

AU - Ramos, Jose T

AU - Warsawski, Josiane

AU - Thorne, Claire

AU - Noguera-Julian, Antoni

AU - Obel, Niels

AU - Costagliola, Dominique

AU - Tookey, Pat A

AU - Colin, Céline

AU - Kjaer, Jesper

AU - Grarup, Jesper

AU - Chene, Genevieve

AU - Phillips, Andrew

AU - Pursuing Later Treatment Options II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)

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N2 - In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

AB - In adults with HIV treated with antiretroviral drug regimens from within the three original drug classes (nucleoside or nucleotide reverse transcriptase inhibitors [NRTIs], non-NRTIs [NNRTIs], and protease inhibitors), virological failure occurs slowly, suggesting that long-term virological suppression can be achieved in most people, even in areas where access is restricted to drugs from these classes. It is unclear whether this is the case for children, the group who will need to maintain viral suppression for longest. We aimed to determine the rate and predictors of triple-class virological failure to the three original drugs classes in children.

KW - Adolescent

KW - Anti-Retroviral Agents

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - HIV Infections

KW - Humans

KW - Infant

KW - Infectious Disease Transmission, Vertical

KW - Kaplan-Meier Estimate

KW - Male

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Risk

KW - Treatment Failure

KW - Viral Load

UR - https://www.scopus.com/pages/publications/79955687620

U2 - 10.1016/S0140-6736(11)60208-0

DO - 10.1016/S0140-6736(11)60208-0

M3 - Journal article

C2 - 21511330

SN - 0140-6736

VL - 377

SP - 1580

EP - 1587

JO - Lancet

JF - Lancet

IS - 9777

ER -

Risk of triple-class virological failure in children with HIV: a retrospective cohort study

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Keywords

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