Abstract
OBJECTIVE: To evaluate the association between subfertility in men and the subsequent risk of testicular cancer.
DESIGN: Population based case-control study.
SETTING: The Danish population.
PARTICIPANTS: Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated.
OUTCOME MEASURE: Occurrence of testicular cancer.
RESULTS: A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors.
CONCLUSION: These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.
| Original language | English |
|---|---|
| Journal | BMJ (Clinical research ed.) |
| Volume | 318 |
| Issue number | 7183 |
| Pages (from-to) | 559-62 |
| Number of pages | 4 |
| ISSN | 0959-8138 |
| DOIs | |
| Publication status | Published - 27 Feb 1999 |
Keywords
- Adolescent
- Adult
- Case-Control Studies
- Humans
- Infertility, Male/complications
- Male
- Middle Aged
- Netherlands/epidemiology
- Odds Ratio
- Paternity
- Risk Factors
- Sexual Partners
- Testicular Neoplasms/complications
Fingerprint
Dive into the research topics of 'Risk of testicular cancer in subfertile men: case-control study'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS