TY - JOUR
T1 - Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark
AU - Glinge, Charlotte
AU - Rossetti, Sára
AU - Oestergaard, Louise Bruun
AU - Stampe, Niels Kjær
AU - Lynge, Thomas Hadberg
AU - Skals, Regitze
AU - Winkel, Bo Gregers
AU - Lodder, Elisabeth M
AU - Bezzina, Connie R
AU - Gislason, Gunnar
AU - Banner, Jytte
AU - Behr, Elijah R
AU - Torp-Pedersen, Christian
AU - Jabbari, Reza
AU - Tfelt-Hansen, Jacob
PY - 2023/1/3
Y1 - 2023/1/3
N2 - IMPORTANCE: Sudden infant death syndrome (SIDS) remains a leading cause of death during the first year of life. The etiology of SIDS is complex and remains largely unknown.OBJECTIVE: To evaluate whether siblings of children who died of SIDS have a higher risk of SIDS compared with the general pediatric population.DESIGN, SETTING, AND PARTICIPANTS: This register-based cohort study used Danish nationwide registers. Participants were all infants (<1 year) in Denmark between January 1, 1978, and December 31, 2016, including siblings of children who died of SIDS. Siblings were followed up from the index cases' date of SIDS, date of birth, or immigration, whichever came first, and until age 1 year, emigration, developing SIDS, death, or study end. The median (IQR) follow-up was 1 (1-1) year. Data analysis was conducted from January 2017 to October 2022.MAIN OUTCOMES AND MEASURES: Standardized incidence ratios (SIRs) of SIDS were calculated with Poisson regression models relative to the general population.RESULTS: In a population of 2 666 834 consecutive births (1 395 199 [52%] male), 1540 infants died of SIDS (median [IQR] age at SIDS, 3 [2-4] months) during a 39-year study period. A total of 2384 younger siblings (cases) to index cases (first sibling with SIDS) were identified. A higher rate of SIDS was observed among siblings compared with the general population, with SIRs of 4.27 (95% CI, 2.13-8.53) after adjustment for sex, age, and calendar year and of 3.50 (95% CI, 1.75-7.01) after further adjustment for mother's age (<29 years vs ≥29 years) and education (high school vs after high school).CONCLUSIONS AND RELEVANCE: In this nationwide study, having a sibling who died of SIDS was associated with a 4-fold higher risk of SIDS compared with the general population. Shared genetic and/or environmental factors may contribute to the observed clustering of SIDS. The family history of SIDS should be considered when assessing SIDS risk in clinical settings. A multidisciplinary genetic evaluation of families with SIDS could provide additional evidence.
AB - IMPORTANCE: Sudden infant death syndrome (SIDS) remains a leading cause of death during the first year of life. The etiology of SIDS is complex and remains largely unknown.OBJECTIVE: To evaluate whether siblings of children who died of SIDS have a higher risk of SIDS compared with the general pediatric population.DESIGN, SETTING, AND PARTICIPANTS: This register-based cohort study used Danish nationwide registers. Participants were all infants (<1 year) in Denmark between January 1, 1978, and December 31, 2016, including siblings of children who died of SIDS. Siblings were followed up from the index cases' date of SIDS, date of birth, or immigration, whichever came first, and until age 1 year, emigration, developing SIDS, death, or study end. The median (IQR) follow-up was 1 (1-1) year. Data analysis was conducted from January 2017 to October 2022.MAIN OUTCOMES AND MEASURES: Standardized incidence ratios (SIRs) of SIDS were calculated with Poisson regression models relative to the general population.RESULTS: In a population of 2 666 834 consecutive births (1 395 199 [52%] male), 1540 infants died of SIDS (median [IQR] age at SIDS, 3 [2-4] months) during a 39-year study period. A total of 2384 younger siblings (cases) to index cases (first sibling with SIDS) were identified. A higher rate of SIDS was observed among siblings compared with the general population, with SIRs of 4.27 (95% CI, 2.13-8.53) after adjustment for sex, age, and calendar year and of 3.50 (95% CI, 1.75-7.01) after further adjustment for mother's age (<29 years vs ≥29 years) and education (high school vs after high school).CONCLUSIONS AND RELEVANCE: In this nationwide study, having a sibling who died of SIDS was associated with a 4-fold higher risk of SIDS compared with the general population. Shared genetic and/or environmental factors may contribute to the observed clustering of SIDS. The family history of SIDS should be considered when assessing SIDS risk in clinical settings. A multidisciplinary genetic evaluation of families with SIDS could provide additional evidence.
UR - http://www.scopus.com/inward/record.url?scp=85146880130&partnerID=8YFLogxK
U2 - 10.1001/jamanetworkopen.2022.52724
DO - 10.1001/jamanetworkopen.2022.52724
M3 - Journal article
C2 - 36696110
VL - 6
SP - e2252724
JO - JAMA network open
JF - JAMA network open
SN - 2574-3805
IS - 1
ER -