Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Risk of Pharmacological or Hospital Treatment for Depression in Patients with Colorectal Cancer-Associations with Pre-Cancer Lifestyle, Comorbidity and Clinical Factors

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities

    Research output: Contribution to journalReviewResearchpeer-review

  2. Nationwide Survival Benefit after Implementation of First-Line Immunotherapy for Patients with Advanced NSCLC-Real World Efficacy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Meningioma-Brain Crosstalk: A Scoping Review

    Research output: Contribution to journalReviewResearchpeer-review

  4. Pathologic Characteristics of Pregnancy-Related Meningiomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark: A nationwide register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Risk of depression after diagnostic prostate cancer workup - A nationwide, registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Is the health literacy of informal caregivers associated with the psychological outcomes of breast cancer survivors?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Incidence of HPV-related Anogenital Intraepithelial Neoplasia and Cancer in Men With Diabetes Compared With the General Population

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Detection of Clinically Significant Prostate Cancer by Systematic TRUS-Biopsies in a Population-Based Setting Over a 20 Year Period

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

We investigated the risk of depression in colorectal cancer (CRC) patients and associated risk factors. The 1324 patients with CRC and 6620 matched cancer-free participants from the Diet, Cancer and Health study were followed for up to 16 years for either a first hospitalization for depression or antidepressant prescription after diagnosis of CRC cancer or study entry date. Information on the outcome and covariates was retrieved from the Danish Colorectal Cancer Group database, the national health registries and questionnaires. Cumulative incidence of depression was estimated, and Cox regression models were used to evaluate the association between risk factors and depression incidence. During follow-up, 191 (14.4%) patients with CRC and 175 (2.6%) cancer-free comparison persons experienced depression. After adjustments, in the first year after cancer diagnosis, patients with CRC had a 12-fold higher hazard compared with the cancer-free population (HR, 12.01; 95% CI, 7.89-18.28). The risk decreased during follow-up but remained significantly elevated with an HR of 2.65 (95% CI, 1.61-4.36) after five years. Identified risk factors were presence of comorbidities, advanced disease stage and use of radiotherapy, while life style factors (pre-cancer or at diagnosis) and chemotherapy did not seem to contribute to the increased risk.

Original languageEnglish
Article number1979
JournalCancers
Volume13
Issue number8
Number of pages12
ISSN2072-6694
DOIs
Publication statusPublished - 20 Apr 2021

    Research areas

  • Cancer survivorship, Colorectal cancer, Depression, Late effects

ID: 67024468