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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Risk of periodontitis in patients with psoriasis and psoriatic arthritis

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BACKGROUND: Psoriasis and periodontitis are chronic inflammatory disorders with overlapping inflammatory pathways, but data on risk of periodontitis in psoriasis are scarce and a possible pathogenic link is poorly understood.

OBJECTIVE: We investigated the association between psoriasis and periodontitis in a nationwide cohort study.

METHODS: All Danish individuals aged ≥18 years between 1 January 1997 and 31 December 2011 (n = 5,470,428), including 54 210 and 6988 patients with mild and severe psoriasis, and 6428 with psoriatic arthritis, were linked through administrative registers. Incidence rate ratios (IRRs) were estimated by Poisson regression.

RESULTS: Incidence rates of periodontitis per 10 000 person-years were 3.07 (3.03-3.12), 5.89 (1.07-6.84), 8.27 (5.50-12.45) and 11.12 (7.87-15.73) for the reference population, mild psoriasis, severe psoriasis and psoriatic arthritis respectively. Adjusted IRRs were (1.66; 1.43-1.94) for mild psoriasis, (2.24; 1.46-3.44) for severe psoriasis and (3.48; 2.46-4.92) for psoriatic arthritis. Similar results were found when a case-control design was applied.

CONCLUSIONS: We found a significant psoriasis-associated increased risk of periodontitis, which was highest in patients with severe psoriasis and psoriatic arthritis.

Original languageEnglish
JournalJournal of the European Academy of Dermatology and Venereology : JEADV
Volume31
Issue number2
Pages (from-to)288-293
Number of pages6
ISSN0926-9959
DOIs
Publication statusPublished - Feb 2017

    Research areas

  • Adolescent, Adult, Arthritis, Psoriatic, Denmark, Female, Humans, Male, Middle Aged, Periodontitis, Psoriasis, Young Adult, Journal Article

ID: 52655391