Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Risk of neurological disorders in patients with European Lyme neuroborreliosis. A nationwide population-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Consensus Hepatitis C Cascade of Care: standardized reporting to monitor progress toward elimination

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term risk of hemorrhagic stroke in patients with infective endocarditis: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Differences in the impact of pneumococcal serotype replacement in individuals with and without underlying medical conditions

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Community-acquired meningitis caused by beta-haemolytic streptococci in adults: a nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Palbociclib in combination with simvastatin induce severe rhabdomyolysis: a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Lyme neuroborreliosis (LNB) caused by the tick-borne spirochetes of the Borrelia burgdorferi sensu lato species complex has been suggested to be associated with a range of neurological disorders. In a nationwide population-based cohort-study we examined the association between LNB and dementia, Alzheimer's disease, Parkinson's disease, motor neuron disease, epilepsy and Guillain-Barré syndrome.

METHODS: We used national registers to identify all Danish residents diagnosed during 1986-2016 with LNB (n=2,067) and a gender and age matched comparison cohort from the general population (n=20,670), and calculated risk estimates and hazard ratios (HR).

RESULTS: We observed no long-term increased risk of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases or epilepsy. However, within the first year eight (0.4%) of the LNB patients developed epilepsy compared with 20 (0.1%) of the comparison cohort (difference 0.3%, 95% CI: 0.02% to 0.6%). In the LNB group 11 (0.5%) patients were diagnosed with Guillain-Barré syndrome within the first year after LNB diagnosis compared with 0 (0.0%) in the comparison cohort. After the first year, the risk of Guillain-Barré was not increased.

CONCLUSION: LNB patients did not have increased long-term risk of dementia, Alzheimer's disease, Parkinson's disease, motor neuron diseases, epilepsy or Guillain-Barré. Although absolute risk is low, LNB patients might have an increased short-term risk of epilepsy and Guillain-Barré syndrome.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN1058-4838
DOIs
Publication statusE-pub ahead of print - 9 Oct 2019

ID: 58139318