Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial

Manan Pareek; Niklas Dyrby Johansen; Daniel Modin; Matthew M. Loiacono; Rebecca C. Harris; Marine Dufournet; Carsten Schade Larsen; Lykke Larsen; Lothar Wiese; Michael Dalager-Pedersen; Brian L. Claggett; Kira Hyldekær Janstrup; Katja Vu Bartholdy; Katrine Feldballe Bernholm; Julie Inge-Marie Helene Borchsenius; Filip Søskov Davidovski; Lise Witten Davodian; Maria Dons; Lisa Steen Duus; Caroline Espersen; Frederik Holme Fussing; Anne Marie Reimer Jensen; Nino Emanuel Landler; Adam Cadovius Femerling Langhoff; Mats Christian Højbjerg Lassen; Anne Bjerg Nielsen; Camilla Ikast Ottosen; Morten Sengeløv; Kristoffer Grundtvig Skaarup; Scott D. Solomon; Martin J. Landray; Gunnar H. Gislason; Lars Køber; Pradeesh Sivapalan; Cyril Jean-Marie Martel; Jens Ulrik Stæhr Jensen; Tor Biering-Sørensen

doi:10.1001/jamanetworkopen.2025.36889

Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial

Manan Pareek, Niklas Dyrby Johansen, Daniel Modin, Matthew M. Loiacono, Rebecca C. Harris, Marine Dufournet, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Brian L. Claggett, Kira Hyldekær Janstrup, Katja Vu Bartholdy, Katrine Feldballe Bernholm, Julie Inge-Marie Helene Borchsenius, Filip Søskov Davidovski, Lise Witten Davodian, Maria Dons, Lisa Steen Duus, Caroline EspersenFrederik Holme Fussing, Anne Marie Reimer Jensen, Nino Emanuel Landler, Adam Cadovius Femerling Langhoff, Mats Christian Højbjerg Lassen, Anne Bjerg Nielsen, Camilla Ikast Ottosen, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Køber, Pradeesh Sivapalan, Cyril Jean-Marie Martel, Jens Ulrik Stæhr Jensen, Tor Biering-Sørensen

Original language	English
Journal	JAMA network open
Volume	8
Issue number	8
Pages (from-to)	e2536889
ISSN	2574-3805
DOIs	https://doi.org/10.1001/jamanetworkopen.2025.36889
Publication status	Published - 1 Aug 2025

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Pareek, M., Johansen, N. D., Modin, D., Loiacono, M. M., Harris, R. C., Dufournet, M., Larsen, C. S., Larsen, L., Wiese, L., Dalager-Pedersen, M., Claggett, B. L., Janstrup, K. H., Bartholdy, K. V., Bernholm, K. F., Borchsenius, J. I.-M. H., Davidovski, F. S., Davodian, L. W., Dons, M., Duus, L. S., ... Biering-Sørensen, T. (2025). Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial. JAMA network open, 8(8), e2536889. https://doi.org/10.1001/jamanetworkopen.2025.36889

Pareek, M , Johansen, ND , Modin, D, Loiacono, MM, Harris, RC, Dufournet, M, Larsen, CS, Larsen, L, Wiese, L, Dalager-Pedersen, M, Claggett, BL, Janstrup, KH , Bartholdy, KV , Bernholm, KF , Borchsenius, JI-MH , Davidovski, FS , Davodian, LW , Dons, M, Duus, LS, Espersen, C , Fussing, FH , Jensen, AMR , Landler, NE , Langhoff, ACF , Lassen, MCH , Nielsen, AB , Ottosen, CI , Sengeløv, M , Skaarup, KG, Solomon, SD, Landray, MJ, Gislason, GH , Køber, L , Sivapalan, P, Martel, CJ-M, Jensen, JUS & Biering-Sørensen, T 2025, 'Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial', JAMA network open, vol. 8, no. 8, pp. e2536889. https://doi.org/10.1001/jamanetworkopen.2025.36889

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title = "Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial",

author = "Manan Pareek and Johansen, \{Niklas Dyrby\} and Daniel Modin and Loiacono, \{Matthew M.\} and Harris, \{Rebecca C.\} and Marine Dufournet and Larsen, \{Carsten Schade\} and Lykke Larsen and Lothar Wiese and Michael Dalager-Pedersen and Claggett, \{Brian L.\} and Janstrup, \{Kira Hyldek{\ae}r\} and Bartholdy, \{Katja Vu\} and Bernholm, \{Katrine Feldballe\} and Borchsenius, \{Julie Inge-Marie Helene\} and Davidovski, \{Filip S{\o}skov\} and Davodian, \{Lise Witten\} and Maria Dons and Duus, \{Lisa Steen\} and Caroline Espersen and Fussing, \{Frederik Holme\} and Jensen, \{Anne Marie Reimer\} and Landler, \{Nino Emanuel\} and Langhoff, \{Adam Cadovius Femerling\} and Lassen, \{Mats Christian H{\o}jbjerg\} and Nielsen, \{Anne Bjerg\} and Ottosen, \{Camilla Ikast\} and Morten Sengel{\o}v and Skaarup, \{Kristoffer Grundtvig\} and Solomon, \{Scott D.\} and Landray, \{Martin J.\} and Gislason, \{Gunnar H.\} and Lars K{\o}ber and Pradeesh Sivapalan and Martel, \{Cyril Jean-Marie\} and Jensen, \{Jens Ulrik St{\ae}hr\} and Tor Biering-S{\o}rensen",

year = "2025",

month = aug,

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doi = "10.1001/jamanetworkopen.2025.36889",

language = "English",

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T1 - Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine

T2 - A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial

AU - Pareek, Manan

AU - Johansen, Niklas Dyrby

AU - Modin, Daniel

AU - Loiacono, Matthew M.

AU - Harris, Rebecca C.

AU - Dufournet, Marine

AU - Larsen, Carsten Schade

AU - Larsen, Lykke

AU - Wiese, Lothar

AU - Dalager-Pedersen, Michael

AU - Claggett, Brian L.

AU - Janstrup, Kira Hyldekær

AU - Bartholdy, Katja Vu

AU - Bernholm, Katrine Feldballe

AU - Borchsenius, Julie Inge-Marie Helene

AU - Davidovski, Filip Søskov

AU - Davodian, Lise Witten

AU - Dons, Maria

AU - Duus, Lisa Steen

AU - Espersen, Caroline

AU - Fussing, Frederik Holme

AU - Jensen, Anne Marie Reimer

AU - Landler, Nino Emanuel

AU - Langhoff, Adam Cadovius Femerling

AU - Lassen, Mats Christian Højbjerg

AU - Nielsen, Anne Bjerg

AU - Ottosen, Camilla Ikast

AU - Sengeløv, Morten

AU - Skaarup, Kristoffer Grundtvig

AU - Solomon, Scott D.

AU - Landray, Martin J.

AU - Gislason, Gunnar H.

AU - Køber, Lars

AU - Sivapalan, Pradeesh

AU - Martel, Cyril Jean-Marie

AU - Jensen, Jens Ulrik Stæhr

AU - Biering-Sørensen, Tor

PY - 2025/8/1

Y1 - 2025/8/1

UR - https://www.scopus.com/pages/publications/105015128357

U2 - 10.1001/jamanetworkopen.2025.36889

DO - 10.1001/jamanetworkopen.2025.36889

M3 - Letter

C2 - 40884443

SN - 2574-3805

VL - 8

SP - e2536889

JO - JAMA network open

JF - JAMA network open

IS - 8

ER -

Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine: A Prespecified Secondary Analysis of the Randomized DANFLU-2 Trial

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