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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition

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  1. Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes

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  2. Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing

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  3. BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population

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  4. No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families

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  5. Germline TERT promoter mutations are rare in familial melanoma

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  1. Detection of PMS2 Mutations by Screening Hereditary Nonpolyposis Colon Cancer Families from Denmark and Sweden

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  2. Implementing mandatory early warning scoring impacts nurses' practice of documenting free text notes

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  3. Rational targeting of population groups and residential areas for colorectal cancer screening

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  4. Publishing your trial protocols with Acta Oncologica; your contribution to scientific transparency

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Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the National Danish Hereditary Nonpolyposis Register. In total, 7100 individuals from families within the subgroups Lynch syndrome, familial CRC (FCC) and moderate risk were used with estimates relative to a non-hereditary population control cohort. SCRC was diagnosed in 7.4% of the Lynch syndrome cases, in 4.2% of FCC cases and 2.5% of the moderate risk cases, which translated to relative risks of 1.9-5.6. The risk of MCRC was distinctively linked to Lynch syndrome with a life-time risk up to 70% and an incidence rate ratio of 5.0. The risk of SCRC was significantly increased in all subgroups of FCC and hereditary CRC, whereas the risk of MCRC was specifically linked to Lynch syndrome. These observations suggest that individuals with FCC or hereditary CRC should be carefully screened for second primary CRC at the time of diagnosis, whereas intensified surveillance for second primary CRC is motivated in Lynch syndrome with lower-intensity programs in families with yet unidentified genetic causes.

Original languageEnglish
JournalFamilial Cancer
Volume18
Issue number2
Pages (from-to)183-191
Number of pages9
ISSN1389-9600
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Colonoscopy, Cross-sectional study, HNPCC, Lynch syndrome, Metachronous neoplasms, Multiple primary neoplasms, Synchronous neoplasms

ID: 55442920