Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Expanding the genotype-phenotype spectrum in hereditary colorectal cancer by gene panel testing

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. BRCA1/BRCA2 founder mutations and cancer risks: impact in the western Danish population

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Germline TERT promoter mutations are rare in familial melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Broadening risk profile in familial colorectal cancer type X; increased risk for five cancer types in the national Danish cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Difficult journeys in sarcoma care; socioeconomic disparity added to the multiple challenges of a rare tumor diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the National Danish Hereditary Nonpolyposis Register. In total, 7100 individuals from families within the subgroups Lynch syndrome, familial CRC (FCC) and moderate risk were used with estimates relative to a non-hereditary population control cohort. SCRC was diagnosed in 7.4% of the Lynch syndrome cases, in 4.2% of FCC cases and 2.5% of the moderate risk cases, which translated to relative risks of 1.9-5.6. The risk of MCRC was distinctively linked to Lynch syndrome with a life-time risk up to 70% and an incidence rate ratio of 5.0. The risk of SCRC was significantly increased in all subgroups of FCC and hereditary CRC, whereas the risk of MCRC was specifically linked to Lynch syndrome. These observations suggest that individuals with FCC or hereditary CRC should be carefully screened for second primary CRC at the time of diagnosis, whereas intensified surveillance for second primary CRC is motivated in Lynch syndrome with lower-intensity programs in families with yet unidentified genetic causes.

Original languageEnglish
JournalFamilial Cancer
Volume18
Issue number2
Pages (from-to)183-191
Number of pages9
ISSN1389-9600
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Colonoscopy, Cross-sectional study, HNPCC, Lynch syndrome, Metachronous neoplasms, Multiple primary neoplasms, Synchronous neoplasms

ID: 55442920