TY - JOUR
T1 - Risk of intensive care unit admission and mortality in patients hospitalized due to influenza A or B and SARS‑CoV‑2 variants Omicron or Delta
AU - Rezahosseini, Omid
AU - Roed, Casper
AU - Sejdic, Adin
AU - Eiberg, Mads Frederik
AU - Nielsen, Lene
AU - Boel, Jonas
AU - Johannesen, Caroline Klint
AU - van Wijhe, Maarten
AU - Franck, Kristina Træholt
AU - Ostrowski, Sisse Rye
AU - Lindegaard, Birgitte
AU - Fischer, Thea K.
AU - Knudsen, Troels Bygum
AU - Holler, Jon Gitz
AU - Harboe, Zitta Barrella
AU - Bagge, Kristian
AU - Jørgensen, Kristina Melbardis
AU - the COVID-19 Omicron Delta study group collaborators
A2 - Lindgaard-Jensen, Betina
A2 - Søborg, Christian
A2 - Nielsen, Thyge Lynghøj
A2 - Bernhard, Peter Haahr
A2 - Pedersen, Emilie Marie Juelstorp
A2 - Egelund, Gertrud Baunbæk
A2 - Mathiesen, Inger Hee Mabuza
A2 - Jespersen, Naja Zenius
A2 - Petersen, Pelle Trier
A2 - Seitz-Rasmussen, Hans Eric Sebastian
A2 - Bertelsen, Barbara Bonnesen
A2 - Bestle, Morten
A2 - Andersen, Henrik
A2 - Skram, Thomas Ulrik
A2 - Altaraihi, Sarah
A2 - Sivapalan, Pradeesh
A2 - Jensen, Jens Ulrik Stæhr
A2 - Ahlström, Magnus Glindvad
A2 - Rytter, Sofie
A2 - le Dous, Nina
A2 - Ravn, Pernille
A2 - Reiter, Nanna
A2 - Podlekareva, Daria
A2 - Knudsen, Jesper Andreas
A2 - Kristensen, Lars Erik
A2 - Leding, Cæcilie
A2 - Benfield, Thomas
A2 - Kirk, Ole
A2 - Sigurdsson, Sigurdur Thor
A2 - Pedersen, Martin Schou
N1 - Publisher Copyright:
© 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
PY - 2024/7
Y1 - 2024/7
N2 - Background: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B). Methods: Data from two retrospective inpatient cohorts in Copenhagen were analyzed. Cohorts included hospitalized influenza A/B patients (2017–2018) and SARS-CoV-2 Delta/Omicron patients (2021–2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen–Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality. Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p <.001) and 1.5 (p =.34) for Delta and Omicron versus influenza B, and 1.5 (p =.36) and 0.71 (p =.48) versus influenza A. For mortality, aHRs were 3.8 (p <.001) and 3.4 (p <.001) for Delta and Omicron versus influenza B, and 2.1 (p =.04) and 1.9 (p =.11) versus influenza A. Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.
AB - Background: Respiratory viral infections have significant global health impacts. We compared 30-day intensive care unit (ICU) admission and all-cause mortality risks in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants versus influenza A and B (A/B). Methods: Data from two retrospective inpatient cohorts in Copenhagen were analyzed. Cohorts included hospitalized influenza A/B patients (2017–2018) and SARS-CoV-2 Delta/Omicron patients (2021–2022), aged ≥18 years, admitted within 14 days of a positive real-time polymerase chain reaction test result. Cumulative ICU admission and mortality rates were estimated using the Aalen–Johansen estimator. Cox regression models calculated hazard ratios (HRs) for ICU admission and mortality. Results: The study encompassed 1459 inpatients (Delta: 49%; Omicron: 26%; influenza A: 6.4%; and influenza B: 18%). Cumulative incidence of ICU admission was 11%, 4.0%, 7.5%, and 4.1%, for Delta, Omicron, influenza A, and B, respectively. For ICU admission, adjusted HRs (aHRs) were 3.1 (p <.001) and 1.5 (p =.34) for Delta and Omicron versus influenza B, and 1.5 (p =.36) and 0.71 (p =.48) versus influenza A. For mortality, aHRs were 3.8 (p <.001) and 3.4 (p <.001) for Delta and Omicron versus influenza B, and 2.1 (p =.04) and 1.9 (p =.11) versus influenza A. Conclusion: Delta but not Omicron inpatients had an increased risk for ICU admission compared to influenza B; however, both variants were associated with higher risks of mortality than influenza B. Only Delta inpatients had a higher risk of mortality than influenza A inpatients.
KW - influenza A
KW - influenza B
KW - intensive care units
KW - mortality
KW - SARS-CoV-2 Delta variants
KW - SARS-CoV-2 Omicron variant
UR - http://www.scopus.com/inward/record.url?scp=85197802004&partnerID=8YFLogxK
U2 - 10.1002/iid3.1269
DO - 10.1002/iid3.1269
M3 - Journal article
AN - SCOPUS:85197802004
SN - 2050-4527
VL - 12
JO - Immunity, Inflammation and Disease
JF - Immunity, Inflammation and Disease
IS - 7
M1 - e1269
ER -