Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Risk of impaired cognition after prenatal exposure to psychotropic drugs

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Cortical thickness following electroconvulsive therapy in patients with depression - a longitudinal MRI study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort)

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The association between depressive mood and ischemic heart disease: a twin study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: Prenatal exposure to psychotropic drugs may affect the trajectories of brain development. In a register study, we investigated whether such exposure is associated with long-term impaired cognitive abilities.

METHOD: Individuals born in Denmark in 1995-2008 were included. As proxies for cognitive impairment, requiring special needs education, attending special needs school, diagnoses of neurological/mental disorder, missed final examinations, and low school grade average were used. We accounted for maternal confounders.

RESULTS: We identified 868 159 individuals of whom 13 983 (1.6%) were prenatally exposed. The adjusted odds ratio (OR) was 0.97[0.92-1.02] for requiring special needs education, 1.28[1.14-1.43] for attending special needs school, 1.32[1.20-1.46] for a neurological/mental disorder diagnosis, 1.37[1.22-1.54] for missing the final examinations, and 1.13[0.82-1.55] for obtaining a low school grade average. Exposure to psycholeptics (primarily antipsychotics and sedatives) was correlated with significantly increased risk for four outcomes. The highest was the risk of missing the primary school examinations (OR: 1.51[1.29-1.76]). The overall highest risk concerned the presence of a neurological/mental disorder after prenatal exposure to psychoanaleptics (primarily antidepressants) (OR: 1.86[1.24-2.78).

CONCLUSION: Prenatal exposure to psychotropic drugs affects proxy outcomes of cognitive disabilities at school age. Exposure to psycholeptics carries the largest risk. The role of psychoanaleptics is currently unclear.

Original languageEnglish
JournalActa Psychiatrica Scandinavica
Volume136
Issue number2
Pages (from-to)177-187
Number of pages11
ISSN0001-690X
DOIs
Publication statusPublished - Aug 2017

    Research areas

  • Journal Article

ID: 51517244