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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Risk of genital warts in renal transplant recipients-A registry-based, prospective cohort study

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  1. Primary Prevention of Skin Dysplasia in Renal Transplant Recipients With Photodynamic Therapy: A Randomized Controlled Trial

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  2. A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism

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  3. Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial

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  1. Shared heritability and functional enrichment across six solid cancers

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  2. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

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  3. Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina

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  4. Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation

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Genital warts (GWs) are a risk factor for subsequent human papillomavirus (HPV)-related anogenital cancers. In this register-based, prospective cohort study, we estimated the risk of GWs in renal transplant recipients (RTRs) compared with a nontransplanted cohort. In a nationwide database, we identified first-time RTRs in Denmark during 1996 to 2015. For each RTR, 50 age- and sex-matched nontransplanted individuals were selected from the population registry. Information on GWs, sociodemographic characteristics, HPV vaccination, and other causes of immunosuppression was retrieved from registries. We estimated the cumulative incidence of GWs and used Cox regression to estimate hazard ratios (HR) of GWs in RTRs vs non-RTRs. We included 3268 RTRs and 162 910 non-RTRs without GWs 1 year before baseline. RTRs had higher hazard of GWs than non-RTRs (HR = 3.30; 95% confidence interval, 2.76-3.93, adjusted for sex, age, education, and income). The increased hazard of GWs compared with non-RTRs was more pronounced in female than in male RTRs. Although not statistically significant, the hazard tended to be higher in RTRs with functioning grafts compared with RTRs on dialysis after graft failure. The hazard of GWs was increased <1 year after transplantation and remained increased during ≥10 years. In conclusion, RTRs had substantially higher risk of GWs than non-RTRs.

Original languageEnglish
JournalAmerican Journal of Transplantation (Online)
Volume19
Issue number1
Pages (from-to)156-165
Number of pages10
ISSN1600-6143
DOIs
Publication statusPublished - Jan 2019

ID: 56089000