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Risk of diabetes among related and unrelated family members

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@article{942261ee45cf4ef9b491f21893126b3f,
title = "Risk of diabetes among related and unrelated family members",
abstract = "AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7{\%}) with diabetes. The RR of diabetes was 2.02 (95{\%} CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95{\%} CI: 1.76-1.83) if a father had diabetes, and 2.06 (95{\%} CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95{\%} CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95{\%} CI: 2.71-2.84) and 5.76 (95{\%} CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95{\%} CI: 2.15-2.56), and with a common father 1.99 (95{\%} CI: 1.81-2.17). Furthermore, the RR was 1.60 (95{\%} CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95{\%} CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.",
author = "Kristian Aasbjerg and {Holm N{\o}rgaard}, Caroline and Nanna Vestergaard and Peter S{\o}gaard and Lars K{\o}ber and Peter Weeke and Gunnar Gislason and Christian Torp-Pedersen",
note = "Copyright {\circledC} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
doi = "10.1016/j.diabres.2019.107997",
language = "English",
volume = "160",
pages = "107997",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Risk of diabetes among related and unrelated family members

AU - Aasbjerg, Kristian

AU - Holm Nørgaard, Caroline

AU - Vestergaard, Nanna

AU - Søgaard, Peter

AU - Køber, Lars

AU - Weeke, Peter

AU - Gislason, Gunnar

AU - Torp-Pedersen, Christian

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020

Y1 - 2020

N2 - AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.

AB - AIMS: The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals.METHODS: We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression.RESULTS: Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates.CONCLUSIONS/INTERPRETATION: Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.

U2 - 10.1016/j.diabres.2019.107997

DO - 10.1016/j.diabres.2019.107997

M3 - Journal article

VL - 160

SP - 107997

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

ER -

ID: 58981777