Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Risk of CIN3 or worse with persistence of 13 individual oncogenic HPV types

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of nonaspirin nonsteroidal anti-inflammatory drugs and risk of head and neck cancer: A nationwide case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Transcriptome-wide association study reveals candidate causal genes for lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cervical cancer risk in women living with HIV across four continents: A multicohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ovarian removal at or after benign hysterectomy and breast cancer: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of nonaspirin nonsteroidal anti-inflammatory drugs and risk of head and neck cancer: A nationwide case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prevalence, type distribution, and risk factors for oral HPV in Danish renal transplant recipients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Human papillomavirus vaccination in immigrants and descendants of immigrants in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cardiovascular Risk Factors and Disease After Male Germ Cell Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Human papillomavirus (HPV) is essential in cervical carcinogenesis, however, less is known about the carcinogenic potential of individual HPV types. Our aim was to examine the risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) after persistence of 13 individual oncogenic HPV types. Liquid-based cervical samples (n = 40,399) collected in 2002–2005 were tested for HPV by hybrid capture 2 and genotyped with INNO-LiPAv2. Persistence was defined as having the same genotype twice 1–4.5 years apart. The absolute risk of CIN3+ was estimated by the Aalen-Johansen estimator and Cox proportional hazard regression was used to compare the rates of CIN3+ according to HPV type adjusting for age and time between HPV tests. Of 2,875 oncogenic HPV-positive women, 874 had persistence of one or more types and 761 persisted for one oncogenic HPV type only. Persistent HPV16 infection was associated with the highest risk of CIN3+, with an 8-year absolute risk of 55% (95% CI: 45%–66%), followed by HPV33 (33% (95% CI: 20%–50%)), HPV18 (32% (95% CI: 20%–48%)) and HPV31 (31% (95% CI: 21%–46%)). Other HPV types, including HPV52 and HPV45, were also associated with high risks. Persistent HPV56 had the lowest 8-year absolute risk of CIN3+ (3% (95% CI: 0.4%–20%)). In Cox analyses, a similar pattern remained after adjustment for age and time between tests. Our results add knowledge about the varying carcinogenic potential of individual persistent oncogenic HPV types, which may have implications for the clinical use of HPV testing.

Original languageEnglish
JournalInternational Journal of Cancer
Volume144
Issue number8
Pages (from-to)1975-1982
Number of pages8
ISSN0020-7136
DOIs
Publication statusPublished - 15 Apr 2019

Bibliographical note

© 2018 UICC.

    Research areas

  • cervical cancer, cervical neoplasia, human papillomavirus, prospective cohort study, type-specific persistence

ID: 55339539