Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Risk of asbestosis, mesothelioma, other lung disease or death among motor vehicle mechanics: a 45-year Danish cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Risk and impact of chronic cough in obese individuals from the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Adverse childhood experiences and asthma: Trajectories in a national cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Low vitamin D and risk of bacterial pneumonias: Mendelian randomisation studies in two population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Beta-blocker use and acute exacerbations of COPD following myocardial infarction: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A longitudinal study of morning, evening, and night light intensities and nocturnal sleep quality in a working population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Professional cleaning and risk of asthma - a Danish nationwide register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Time course of symptoms in posttraumatic stress disorder with delayed expression: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

INTRODUCTION: The risk of asbestosis, malignant mesothelioma and lung cancer among motor vehicle mechanics is of concern because of potential exposure to chrysotile asbestos during brake, clutch and gasket repair and maintenance. Asbestos has also been used in insulation and exhaust systems.

METHODS: We examined the long-term risk of incident mesothelioma, lung cancer, asbestosis and other lung diseases and mortality due to mesothelioma, lung cancer, asbestosis and other lung diseases in a nationwide cohort of all men registered as motor vehicle mechanics since 1970 in Denmark. This was compared with the corresponding risk in a cohort of male workers matched 10:1 by age and calendar year, with similar socioeconomic status (instrument makers, dairymen, upholsterers, glaziers, butchers, bakers, drivers, farmers and workers in the food industry, trade or public services).

RESULTS: Our study included 138 559 motor vehicle mechanics (median age 24 years; median follow-up 20 years (maximum 45 years)) and 1 385 590 comparison workers (median age 25 years; median follow-up 19 years (maximum 45 years)). Compared with other workers, vehicle mechanics had a lower risk of morbidity due to mesothelioma/pleural cancer (n=47 cases) (age-adjusted and calendar-year-adjusted HR=0.74 (95% CI 0.55 to 0.99)), a slightly increased risk of lung cancer (HR=1.09 (95% CI 1.03 to 1.14)), increased risk of asbestosis (HR=1.50 (95% CI 1.10 to 2.03)) and a chronic obstructive pulmonary disease risk close to unity (HR=1.02 (95% CI 0.99 to 1.05)). Corresponding HRs for mortality were 0.86 (95% CI 0.64 to 1.15) for mesothelioma/pleural cancer, 1.06 (95% CI 1.01 to 1.12) for lung cancer, 1.79 (95% CI 1.10 to 2.92) for asbestosis, 1.06 (95% CI 0.86 to 1.30) for other lung diseases caused by external agents and 1.00 (95% CI 0.98 to 1.01) for death due to all causes.

CONCLUSIONS: We found that the risk of asbestosis was increased among vehicle mechanics. The risk of malignant mesothelioma/pleural cancers was not increased among vehicle mechanics.

Original languageEnglish
JournalThorax
Volume77
Issue number5
Pages (from-to)477-485
Number of pages9
ISSN0040-6376
DOIs
Publication statusPublished - May 2022

Bibliographical note

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

    Research areas

  • asbestos induced lung disease, clinical epidemiology, lung cancer, mesothelioma, occupational lung disease

ID: 72730096