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Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age

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Harvard

Frederiksen, LE, Ernst, A, Brix, N, Braskhøj Lauridsen, LL, Roos, L, Ramlau-Hansen, CH & Ekelund, CK 2018, 'Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age', Obstetrics and Gynecology, vol. 131, no. 3, pp. 457-463. https://doi.org/10.1097/AOG.0000000000002504

APA

Frederiksen, L. E., Ernst, A., Brix, N., Braskhøj Lauridsen, L. L., Roos, L., Ramlau-Hansen, C. H., & Ekelund, C. K. (2018). Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. Obstetrics and Gynecology, 131(3), 457-463. https://doi.org/10.1097/AOG.0000000000002504

CBE

Frederiksen LE, Ernst A, Brix N, Braskhøj Lauridsen LL, Roos L, Ramlau-Hansen CH, Ekelund CK. 2018. Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. Obstetrics and Gynecology. 131(3):457-463. https://doi.org/10.1097/AOG.0000000000002504

MLA

Vancouver

Frederiksen LE, Ernst A, Brix N, Braskhøj Lauridsen LL, Roos L, Ramlau-Hansen CH et al. Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. Obstetrics and Gynecology. 2018 Mar;131(3):457-463. https://doi.org/10.1097/AOG.0000000000002504

Author

Frederiksen, Line Elmerdahl ; Ernst, Andreas ; Brix, Nis ; Braskhøj Lauridsen, Lea Lykke ; Roos, Laura ; Ramlau-Hansen, Cecilia Høst ; Ekelund, Charlotte Kvist. / Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age. In: Obstetrics and Gynecology. 2018 ; Vol. 131, No. 3. pp. 457-463.

Bibtex

@article{e172b603cf2e4dccbc98ff14ceba6bf2,
title = "Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age",
abstract = "OBJECTIVE: To study the possible associations between advanced maternal age and risk of selected adverse pregnancy outcomes.METHODS: The study used a nationwide cohort of 369,516 singleton pregnancies in Denmark followed from 11-14 weeks of gestation to delivery or termination of pregnancy. Pregnant women aged 35 years or older were divided into two advanced maternal age groups, 35-39 years and 40 years or older, and compared with pregnant women aged 20-34 years. Adverse pregnancy outcomes were chromosomal abnormalities, congenital malformations, miscarriage, stillbirth, and birth before 34 weeks of gestation. Multivariable logistic regression analyses were performed to investigate associations between advanced maternal age and adverse pregnancy outcomes. Furthermore, a risk prediction model for a composite adverse pregnancy outcome was made with prespecified predicting factors.RESULTS: Among the pregnant women aged 40 years or older, 10.82% experienced one or more of the selected adverse pregnancy outcomes compared with 5.46% of pregnant women aged 20-34 years (odds ratio [OR] 2.02, 99.8% CI 1.78-2.29). When pregnant women 40 years or older were compared with women aged 20-34 years, they had a higher risk of chromosomal abnormalities (3.83% vs 0.56%, OR 7.44 [CI 5.93-9.34]), miscarriage (1.68% vs 0.42%, OR 3.10 [CI 2.19-4.38]), and birth before 34 weeks of gestation (2.01% vs 1.21%, OR 1.66 [CI 1.23-2.24]), but no increased risk of congenital malformations and stillbirth. The risk prediction chart showed that advanced maternal age, use of assisted reproductive technology, nulliparous pregnancy, smoking during pregnancy, and obesity increased the absolute predictive risk of an adverse pregnancy outcome.CONCLUSION: Women older than 40 years have a higher risk of chromosomal abnormalities, miscarriage, and birth before 34 weeks of gestation than younger women and should be monitored accordingly. No increased risk was observed for stillbirth and other congenital malformations. Several factors increase the risk of adverse pregnancy outcomes, but advanced maternal age drives a high proportion of the total risk score.",
author = "Frederiksen, {Line Elmerdahl} and Andreas Ernst and Nis Brix and {Braskh{\o}j Lauridsen}, {Lea Lykke} and Laura Roos and Ramlau-Hansen, {Cecilia H{\o}st} and Ekelund, {Charlotte Kvist}",
year = "2018",
month = mar,
doi = "10.1097/AOG.0000000000002504",
language = "English",
volume = "131",
pages = "457--463",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age

AU - Frederiksen, Line Elmerdahl

AU - Ernst, Andreas

AU - Brix, Nis

AU - Braskhøj Lauridsen, Lea Lykke

AU - Roos, Laura

AU - Ramlau-Hansen, Cecilia Høst

AU - Ekelund, Charlotte Kvist

PY - 2018/3

Y1 - 2018/3

N2 - OBJECTIVE: To study the possible associations between advanced maternal age and risk of selected adverse pregnancy outcomes.METHODS: The study used a nationwide cohort of 369,516 singleton pregnancies in Denmark followed from 11-14 weeks of gestation to delivery or termination of pregnancy. Pregnant women aged 35 years or older were divided into two advanced maternal age groups, 35-39 years and 40 years or older, and compared with pregnant women aged 20-34 years. Adverse pregnancy outcomes were chromosomal abnormalities, congenital malformations, miscarriage, stillbirth, and birth before 34 weeks of gestation. Multivariable logistic regression analyses were performed to investigate associations between advanced maternal age and adverse pregnancy outcomes. Furthermore, a risk prediction model for a composite adverse pregnancy outcome was made with prespecified predicting factors.RESULTS: Among the pregnant women aged 40 years or older, 10.82% experienced one or more of the selected adverse pregnancy outcomes compared with 5.46% of pregnant women aged 20-34 years (odds ratio [OR] 2.02, 99.8% CI 1.78-2.29). When pregnant women 40 years or older were compared with women aged 20-34 years, they had a higher risk of chromosomal abnormalities (3.83% vs 0.56%, OR 7.44 [CI 5.93-9.34]), miscarriage (1.68% vs 0.42%, OR 3.10 [CI 2.19-4.38]), and birth before 34 weeks of gestation (2.01% vs 1.21%, OR 1.66 [CI 1.23-2.24]), but no increased risk of congenital malformations and stillbirth. The risk prediction chart showed that advanced maternal age, use of assisted reproductive technology, nulliparous pregnancy, smoking during pregnancy, and obesity increased the absolute predictive risk of an adverse pregnancy outcome.CONCLUSION: Women older than 40 years have a higher risk of chromosomal abnormalities, miscarriage, and birth before 34 weeks of gestation than younger women and should be monitored accordingly. No increased risk was observed for stillbirth and other congenital malformations. Several factors increase the risk of adverse pregnancy outcomes, but advanced maternal age drives a high proportion of the total risk score.

AB - OBJECTIVE: To study the possible associations between advanced maternal age and risk of selected adverse pregnancy outcomes.METHODS: The study used a nationwide cohort of 369,516 singleton pregnancies in Denmark followed from 11-14 weeks of gestation to delivery or termination of pregnancy. Pregnant women aged 35 years or older were divided into two advanced maternal age groups, 35-39 years and 40 years or older, and compared with pregnant women aged 20-34 years. Adverse pregnancy outcomes were chromosomal abnormalities, congenital malformations, miscarriage, stillbirth, and birth before 34 weeks of gestation. Multivariable logistic regression analyses were performed to investigate associations between advanced maternal age and adverse pregnancy outcomes. Furthermore, a risk prediction model for a composite adverse pregnancy outcome was made with prespecified predicting factors.RESULTS: Among the pregnant women aged 40 years or older, 10.82% experienced one or more of the selected adverse pregnancy outcomes compared with 5.46% of pregnant women aged 20-34 years (odds ratio [OR] 2.02, 99.8% CI 1.78-2.29). When pregnant women 40 years or older were compared with women aged 20-34 years, they had a higher risk of chromosomal abnormalities (3.83% vs 0.56%, OR 7.44 [CI 5.93-9.34]), miscarriage (1.68% vs 0.42%, OR 3.10 [CI 2.19-4.38]), and birth before 34 weeks of gestation (2.01% vs 1.21%, OR 1.66 [CI 1.23-2.24]), but no increased risk of congenital malformations and stillbirth. The risk prediction chart showed that advanced maternal age, use of assisted reproductive technology, nulliparous pregnancy, smoking during pregnancy, and obesity increased the absolute predictive risk of an adverse pregnancy outcome.CONCLUSION: Women older than 40 years have a higher risk of chromosomal abnormalities, miscarriage, and birth before 34 weeks of gestation than younger women and should be monitored accordingly. No increased risk was observed for stillbirth and other congenital malformations. Several factors increase the risk of adverse pregnancy outcomes, but advanced maternal age drives a high proportion of the total risk score.

U2 - 10.1097/AOG.0000000000002504

DO - 10.1097/AOG.0000000000002504

M3 - Journal article

C2 - 29420406

VL - 131

SP - 457

EP - 463

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -

ID: 56085865