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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Risk Factors for Premature Death in Diabetes Patients who Undergo Amputations below Ankle Level

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  1. The Diabetic Foot in a Multidisciplinary Team Setting. Number of Amputations below Ankle Level and Mortality

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  2. Insulin-like growth factor I and anthropometric parameters in a Danish population

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  3. Metabolic effects of short-term GLP-1 treatment in insulin resistant heart failure patients

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  4. Thyrocyte-interleukin-1 interactions

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  1. Mortality and complications after treatment of acute diabetic Charcot foot

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  2. A review of bone metabolism and developments in medical treatment of the diabetic Charcot foot

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  3. Long-term effects on the progress of neuropathy after diabetic Charcot foot: an 8.5-year prospective case-control study

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  4. Livskvalitet - det er til for patienten

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AIM: To identify risk factors for early death in diabetes patients who undergo amputations below the ankle.

METHODS: A retrospective study, where all hospital records of all diabetes patients who had undergone minimum one amputation below the ankle at the CWHC Bispebjerg Hospital, Denmark, in the period 1996-2013, were examined. The amputations were mainly trans-metatarsal amputations and partial amputations of toes. The participants were found via ICD10-codes. The included patients were followed from their first contact to the last registered contact. The statistical analysis in this article is performed on patients with a of minimum 5-year follow-up.

RESULTS: The 5 year mortality was 42% for patients with type 2 diabetes, and 29% for patients with type 1 diabetes. For patients with type 2 diabetes, multivariable analysis showed that high age, peripheral arterial insufficiency and short time from first admission to amputation were independently statistically significantly associated with increased 5-years mortality. Use of statins was associated with decreased mortality. 35% died as a result of their diabetes, mostly due to cardiovascular causes.

CONCLUSION: Short time from first admission to amputation is a risk factor for early death. Arterial insufficiency and high age is also associated with increased mortality, whereas use of statin is associated with decreased mortality, in patients with type 2 diabetes.

Original languageGerman
JournalExperimental and Clinical Endocrinology and Diabetes
Volume126
Issue number1
Pages (from-to)61-65
Number of pages5
ISSN0947-7349
DOIs
Publication statusPublished - Jan 2018

ID: 56256329