Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Kristina Öbrink-Hansen; Ole S Søgaard; Zitta B Harboe; Henrik C Schønheyder

doi:10.2174/157016212800618101

Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Kristina Öbrink-Hansen, Ole S Søgaard, Zitta B Harboe, Henrik C Schønheyder

2 Citations (Scopus)

Abstract

HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

Original language	English
Journal	Current HIV research
Volume	10
Issue number	3
Pages (from-to)	252-5
Number of pages	4
ISSN	1570-162X
DOIs	https://doi.org/10.2174/157016212800618101
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

AIDS-Related Opportunistic Infections/immunology
CD4-Positive T-Lymphocytes
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Cohort Studies
Colony Count, Microbial
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nasopharynx/microbiology
Pneumococcal Infections/immunology
Pneumococcal Vaccines/immunology
Randomized Controlled Trials as Topic
Risk Factors
Smoking/adverse effects
Streptococcus pneumoniae/growth & development
Vaccines, Conjugate/immunology

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10.2174/157016212800618101

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title = "Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report",

abstract = "HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23\%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.",

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author = "Kristina {\"O}brink-Hansen and S{\o}gaard, \{Ole S\} and Harboe, \{Zitta B\} and Sch{\o}nheyder, \{Henrik C\}",

year = "2012",

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doi = "10.2174/157016212800618101",

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T1 - Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV

T2 - brief report

AU - Öbrink-Hansen, Kristina

AU - Søgaard, Ole S

AU - Harboe, Zitta B

AU - Schønheyder, Henrik C

PY - 2012/4

Y1 - 2012/4

N2 - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

AB - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

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KW - Follow-Up Studies

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KW - Male

KW - Middle Aged

KW - Nasopharynx/microbiology

KW - Pneumococcal Infections/immunology

KW - Pneumococcal Vaccines/immunology

KW - Randomized Controlled Trials as Topic

KW - Risk Factors

KW - Smoking/adverse effects

KW - Streptococcus pneumoniae/growth & development

KW - Vaccines, Conjugate/immunology

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SN - 1570-162X

VL - 10

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EP - 255

JO - Current HIV research

JF - Current HIV research

IS - 3

ER -

Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

Abstract

Keywords

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