Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data

Mathias Ørholt; Frederik L Aaberg; Kiya Abebe; S Walsh; Randall K Roenigk; Alessandro Venzo; Grethe Schmidt; Helle Klyver; David H Jensen; Mikkel Herly; Peter V Vester-Glowinski

doi:10.1002/jso.26898

Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data

Mathias Ørholt^*, Frederik L Aaberg, Kiya Abebe, S Walsh, Randall K Roenigk, Alessandro Venzo, Grethe Schmidt, Helle Klyver, David H Jensen, Mikkel Herly, Peter V Vester-Glowinski

^*Corresponding author for this work

Department of Plastic Surgery and Burns Treatment

7 Citations (Scopus)

Abstract

BACKGROUND: Risk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.

OBJECTIVE: To identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.

METHODS AND MATERIALS: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan-Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.

RESULTS: Five hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78-30.0], p < 0.01 and HR: 2.89 [95% CI: 1.04-8.01], p < 0.05, respectively). There was no difference when comparing wide local excision and Mohs' micrographic surgery (p = 0.89). The risks of local AFX recurrence and progression to PDS after 2 years were <1%.

CONCLUSION: A more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence.

Original language	English
Journal	Journal of Surgical Oncology
Volume	126
Issue number	3
Pages (from-to)	555-562
Number of pages	8
ISSN	0022-4790
DOIs	https://doi.org/10.1002/jso.26898
Publication status	Published - Sept 2022

Keywords

atypical fibroxanthoma
Mohs
oncology
skin cancer

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10.1002/jso.26898

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Ørholt, M., Aaberg, F. L., Abebe, K., Walsh, S., Roenigk, R. K., Venzo, A., Schmidt, G., Klyver, H., Jensen, D. H., Herly, M., & Vester-Glowinski, P. V. (2022). Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data. Journal of Surgical Oncology, 126(3), 555-562. https://doi.org/10.1002/jso.26898

Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data. / Ørholt, Mathias ; Aaberg, Frederik L ; Abebe, Kiya et al.
In: Journal of Surgical Oncology, Vol. 126, No. 3, 09.2022, p. 555-562.

Research output: Contribution to journal › Journal article › Research › peer-review

Ørholt, M , Aaberg, FL , Abebe, K, Walsh, S, Roenigk, RK, Venzo, A , Schmidt, G , Klyver, H , Jensen, DH , Herly, M & Vester-Glowinski, PV 2022, 'Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data', Journal of Surgical Oncology, vol. 126, no. 3, pp. 555-562. https://doi.org/10.1002/jso.26898

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abstract = "BACKGROUND: Risk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.OBJECTIVE: To identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.METHODS AND MATERIALS: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan-Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.RESULTS: Five hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78-30.0], p < 0.01 and HR: 2.89 [95% CI: 1.04-8.01], p < 0.05, respectively). There was no difference when comparing wide local excision and Mohs' micrographic surgery (p = 0.89). The risks of local AFX recurrence and progression to PDS after 2 years were <1%.CONCLUSION: A more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence.",

keywords = "atypical fibroxanthoma, Mohs, oncology, skin cancer",

author = "Mathias {\O}rholt and Aaberg, {Frederik L} and Kiya Abebe and S Walsh and Roenigk, {Randall K} and Alessandro Venzo and Grethe Schmidt and Helle Klyver and Jensen, {David H} and Mikkel Herly and Vester-Glowinski, {Peter V}",

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doi = "10.1002/jso.26898",

language = "English",

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T1 - Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma

T2 - A meta-analysis of individualized participant data

AU - Ørholt, Mathias

AU - Aaberg, Frederik L

AU - Abebe, Kiya

AU - Walsh, S

AU - Roenigk, Randall K

AU - Venzo, Alessandro

AU - Schmidt, Grethe

AU - Klyver, Helle

AU - Jensen, David H

AU - Herly, Mikkel

AU - Vester-Glowinski, Peter V

PY - 2022/9

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N2 - BACKGROUND: Risk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.OBJECTIVE: To identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.METHODS AND MATERIALS: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan-Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.RESULTS: Five hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78-30.0], p < 0.01 and HR: 2.89 [95% CI: 1.04-8.01], p < 0.05, respectively). There was no difference when comparing wide local excision and Mohs' micrographic surgery (p = 0.89). The risks of local AFX recurrence and progression to PDS after 2 years were <1%.CONCLUSION: A more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence.

AB - BACKGROUND: Risk factors for local atypical fibroxanthoma (AFX) recurrence and progression to pleomorphic dermal sarcoma (PDS) have not previously been identified.OBJECTIVE: To identify risk factors and provide follow-up suggestions for local AFX recurrence and progression to PDS.METHODS AND MATERIALS: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. The PRISMA and MOOSE guidelines were followed. The risks of local AFX recurrence and progression to PDS were presented as Kaplan-Meier plots and risk factors were presented as hazard ratios (HRs) calculated with univariate and multivariate Cox regression.RESULTS: Five hundred and ninety-eight patients with AFX from 14 studies were included. Age >74 years and male sex significantly increased the risk of local recurrence (HR: 7.31 [95% confidence interval [CI]: 1.78-30.0], p < 0.01 and HR: 2.89 [95% CI: 1.04-8.01], p < 0.05, respectively). There was no difference when comparing wide local excision and Mohs' micrographic surgery (p = 0.89). The risks of local AFX recurrence and progression to PDS after 2 years were <1%.CONCLUSION: A more intensive follow-up regimen could be considered in patients >74 years old and males due to the higher risk of local AFX recurrence.

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JO - Journal of Surgical Oncology

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Risk factors for local atypical fibroxanthoma recurrence and progression to pleomorphic dermal sarcoma: A meta-analysis of individualized participant data

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