Risk factors for development of nephropathy in patients with a diabetic Charcot foot

Abstract

OBJECTIVE: Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function.

RESULTS: In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.

Original languageEnglish
Article number403
JournalBMC Research Notes
Volume14
Issue number1
Pages (from-to)403
ISSN1756-0500
DOIs
Publication statusPublished - 30 Oct 2021

Keywords

  • Arthropathy, Neurogenic
  • Diabetes Mellitus
  • Diabetic Foot/complications
  • Diabetic Neuropathies
  • Humans
  • Peripheral Nervous System Diseases
  • Retrospective Studies
  • Risk Factors

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