Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Rising incidence of Merkel cell carcinoma

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Surgical techniques for repair of abdominal rectus diastasis: a scoping review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Patient-reported outcomes following interposition arthroplasty of the basal joint of the thumb

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation

    Research output: Contribution to journalReviewResearchpeer-review

  4. The Danish Scale for visual rating of massive weight loss body contours. Conceptualization and construct

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Patient-and observer-reported long-term scar quality of wide local excision scars in melanoma patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Factors associated with melanoma-related limb lymphoedema

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Abstract Merkel cell carcinoma (MCC) is a rare, aggressive, skin cancer of obscure histogenesis, the incidence of which is rising. There is no consensus on the optimal treatment. Our aim was to evaluate the staging, investigation, treatment, and follow-up of MCC in eastern Denmark, and to investigate the incidence. We suggest guidelines for treatment. First we reviewed the medical records of 51 patients diagnosed with MCC from 1995 until 2006 in eastern Denmark. The nation-wide incidence of MCC was extracted from the Danish Cancer Registry for the calculations for the period 1986-2003. We reviwed published papers about MCC based on a MEDLINE search. Fourteen of the 51 patients developed recurrence, and 37 (73%) died during the study period. Mean follow-up was 13 months (range 1-122). A total of 153 patients were identified in the Danish Cancer Registry, and showed that incidence rates had increased 5.4 fold over the 18 year period from 1986 until 2003. Rates were highest in people over the age of 65. Recommended treatment with curative intent includes excision of the primary tumour with wide margins, excision of the sentinel node, computed tomogram (CT) or positron emission tomography (PET) of the thorax and abdomen, and adjuvant radiotherapy to the surgical bed. In the case of advanced disease, systemic palliative chemotherapy remains a possibility. There is a need for prospective multicentre evaluation of staging investigations and treatment of MCC.
Original languageEnglish
JournalJournal of Plastic Surgery and Hand Surgery
Volume45
Issue number6
Pages (from-to)274-80
Number of pages7
ISSN2000-656X
DOIs
Publication statusPublished - 2011

ID: 33257622