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Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization - Proof of concept study

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@article{f80e7a64b1234ace854805e7e6d598f6,
title = "Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization - Proof of concept study",
abstract = "BACKGROUND: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage.AIM: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage.METHODS: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution.FINDINGS: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively.CONCLUSION: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.",
author = "Petersen, {Ina Sleimann} and Zeuthen, {Anne Bak} and Christensen, {Judit Marta} and Bartels, {Mette Damkj{\ae}r} and {Neustrup Johansen}, {Helle Henny} and Johansen, {Suzanne Pollas} and Jarl{\o}v, {Jens Otto} and Dorthe Mogensen and Janne Pedersen",
note = "Copyright {\textcopyright} 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.",
year = "2022",
month = jan,
doi = "10.1016/j.jhin.2021.09.025",
language = "English",
volume = "119",
pages = "16--21",
journal = "Journal of Hospital Infection",
issn = "0195-6701",
publisher = "W.B./Saunders Co. Ltd",

}

RIS

TY - JOUR

T1 - Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization - Proof of concept study

AU - Petersen, Ina Sleimann

AU - Zeuthen, Anne Bak

AU - Christensen, Judit Marta

AU - Bartels, Mette Damkjær

AU - Neustrup Johansen, Helle Henny

AU - Johansen, Suzanne Pollas

AU - Jarløv, Jens Otto

AU - Mogensen, Dorthe

AU - Pedersen, Janne

N1 - Copyright © 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

PY - 2022/1

Y1 - 2022/1

N2 - BACKGROUND: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage.AIM: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage.METHODS: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution.FINDINGS: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively.CONCLUSION: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.

AB - BACKGROUND: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage.AIM: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage.METHODS: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution.FINDINGS: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively.CONCLUSION: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.

UR - http://www.scopus.com/inward/record.url?scp=85120612135&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2021.09.025

DO - 10.1016/j.jhin.2021.09.025

M3 - Journal article

C2 - 34699965

VL - 119

SP - 16

EP - 21

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

ER -

ID: 68561709