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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Rhabdomyolysis following interferon-beta treatment in a patient with multiple sclerosis - A case report

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BACKGROUND: Multiple sclerosis is an inflammatory disease of the central nervous system for which there is currently no cure. Interferon-beta-1-alpha is worldwide one of the most widely used treatments in multiple sclerosis. To our knowledge there is one previous reported case of rhabdomyolysis associated with Interferon-beta treatment.

CASE PRESENTATION: We describe a 30 year old man with relapsing remitting multiple sclerosis who developed rhabdomyolysis and increased creatine kinase following Interferon-beta-1-alpha therapy. After the medication was discontinued, the patient rapidly improved.

CONCLUSION: Clinicians should be aware of the possibility of rhabdomyolysis occurring during Interferon-beta-1-alpha therapy. In cases where patients complain of severe myalgia, and in particular if weakness is reported, creatine kinase activity should be measured to prevent irreversible rhabdomyolysis during Interferon-beta-1-alpha therapy in patients with multiple sclerosis.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume8
Pages (from-to)93-5
Number of pages3
ISSN2211-0348
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Journal Article

ID: 49729477