Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study

Iben F Sorgenfrei; Kathrine Norrild; Per Bo Larsen; Jakob Stensballe; Doris Ostergaard; Martine E Prins; Jørgen Viby-Mogensen

Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study

Iben F Sorgenfrei, Kathrine Norrild, Per Bo Larsen, Jakob Stensballe, Doris Ostergaard, Martine E Prins, Jørgen Viby-Mogensen

312 Citations (Scopus)

Abstract

Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block.

Original language	English
Journal	Anesthesiology
Volume	104
Issue number	4
Pages (from-to)	667-74
Number of pages	8
ISSN	0003-3022
Publication status	Published - 1 Apr 2006

Keywords

Adolescent
Adult
Androstanols
Dose-Response Relationship, Drug
Humans
Male
Middle Aged
Neuromuscular Blockade
Neuromuscular Nondepolarizing Agents
gamma-Cyclodextrins

Cite this

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title = "Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study",

abstract = "Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block.",

keywords = "Adolescent, Adult, Androstanols, Dose-Response Relationship, Drug, Humans, Male, Middle Aged, Neuromuscular Blockade, Neuromuscular Nondepolarizing Agents, gamma-Cyclodextrins",

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T1 - Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study

AU - Sorgenfrei, Iben F

AU - Norrild, Kathrine

AU - Larsen, Per Bo

AU - Stensballe, Jakob

AU - Ostergaard, Doris

AU - Prins, Martine E

AU - Viby-Mogensen, Jørgen

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block.

AB - Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block.

KW - Adolescent

KW - Adult

KW - Androstanols

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Male

KW - Middle Aged

KW - Neuromuscular Blockade

KW - Neuromuscular Nondepolarizing Agents

KW - gamma-Cyclodextrins

M3 - Journal article

C2 - 16571960

SN - 0003-3022

VL - 104

SP - 667

EP - 674

JO - Anesthesiology

JF - Anesthesiology

IS - 4

ER -

Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study

Abstract

Keywords

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