Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Obesity remains a major risk factor associated with vascular stiffening in type 2 diabetes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Left ventricular hypertrophy identified by cardiac computed tomography and ECG in hypertensive individuals: a population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Psychotic experiences from preadolescence to adolescence: when should we be worried about adolescent risk behaviors?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Low physical activity and higher use of screen devices are associated with myopia at the age of 16-17 years in the CCC2000 Eye Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cohort Profile: The Copenhagen Child Cohort Study (CCC2000)

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: To study the thickness of retinal arteriolar walls in a population-based cohort of adolescents. METHODS: This cross-sectional, observational study included 1217 participants aged 16-17 years from the Copenhagen Child Cohort 2000 Study. The wall thickness and lumen diameter of a major branch retinal arteriole were measured using adaptive optics imaging. The wall-to-lumen ratio was analyzed in relation to blood pressure and body composition variables using a general linear model. Overall in the study population, wall-to-lumen ratio was found to decrease by 0.49% per μm increase in arteriole diameter (P < 0.0001) and all subsequent analyzes were adjusted accordingly. RESULTS: The average outer and inner arteriole diameters were 117 ± 19 and 96.6 ± 18 μm (mean ± SD), corresponding to a wall-to-lumen ratio of 0.21 ± 0.024. There was no detectable difference between sexes. A higher wall-to-lumen ratio was associated with a higher BMI (+0.21% per kg/m, P = 0.0018), higher body fat percentage (+0.097% per 1% increase, P = 0.0052), wider hip circumference (+1.1% per 10 cm increase, P = 0.0006), wider waist circumference (+0.92% per 10 cm increase, P = 0.0009), higher SBP in girls (+1.1% per 10 mmHg increase, P = 0.0005), longer axial length (+0.70% per mm increase, P = 0.013), and younger age (+4.9% per year younger, P < 0.0001), adjusted for arteriole diameter, age, sex, and height. CONCLUSION: A higher retinal arteriolar wall-to-lumen ratio was associated with all registered indices of body fat proportion.

Original languageEnglish
JournalJournal of Hypertension
Volume38
Issue number4
Pages (from-to)731-736
Number of pages6
ISSN0263-6352
DOIs
Publication statusPublished - Apr 2020

ID: 58627395