Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Editorial: Novel Biomarkers for Type 2 Diabetes

    Research output: Contribution to journalEditorialResearchpeer-review

  2. Editorial: The Role of Genetic and Lifestyle Factors in Metabolic Diseases

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND AND OBJECTIVES: Ambiguous results have been reported regarding the effects of training on resting metabolic rate (RMR), and the importance of training type and intensity is unclear. Moreover, studies in subjects with type 2 diabetes (T2D) are sparse. In this study, we evaluated the effects of interval and continuous training on RMR in subjects with T2D. Furthermore, we explored the determinants for training-induced alterations in RMR.

METHODS: Data from two studies, both including T2D subjects, were encompassed in this manuscript. Study 1 was a randomized, crossover study where subjects (n = 14) completed three, 2-week interventions [control, continuous walking training (CWT), interval-walking training (IWT)] separated by washout periods. Training included 10 supervised treadmill sessions, 60 min/session. CWT was performed at moderate walking speed [aiming for 73% of walking peak oxygen uptake (VO2peak)], while IWT was performed as alternating 3-min repetitions at slow (54% VO2peak) and fast (89% VO2peak) walking speed. Study 2 was a single-arm training intervention study where subjects (n = 23) were prescribed 12 weeks of free-living IWT (at least 3 sessions/week, 30 min/session). Before and after interventions, RMR, physical fitness, body composition, and glycemic control parameters were assessed.

RESULTS: No overall intervention-induced changes in RMR were seen across the studies, but considerable inter-individual differences in RMR changes were seen in Study 2. At baseline, total body mass (TBM), fat-free mass (FFM), and fat mass were all associated with RMR. Changes in RMR were associated with changes in TBM and fat mass, and subjects who decreased body mass and fat mass also decreased their RMR. No associations were seen between changes in physical fitness, glycemic control, or FFM and changes in RMR.

CONCLUSION: Neither short-term continuous or interval-type training, nor longer term interval training affects RMR in subjects with T2D when no overall changes in body composition are seen. If training occurs concomitant with a reduction in fat mass, however, RMR is decreased.

CLINICAL TRIALS REGISTRATION WWWCLINICALTRIALSGOV: NCT02320526 and NCT02089477.

Original languageEnglish
JournalFrontiers in Endocrinology
Volume8
Pages (from-to)e132
ISSN1664-2392
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

ID: 52791226