Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Response to Biologics During the First Six Months of Therapy in Biologic-naïve Patients with Psoriasis Predicts Risk of Disease Flares: A Danish Nationwide Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Wearing Occlusive Gloves Increases the Density of Staphylococcus aureus in Patients with Hand Eczema

    Research output: Contribution to journalJournal articleResearch

  2. Characterization of the Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Epidemiology of Hyperhidrosis in Danish Blood Donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vaccination Granuloma Itch Treated with Capsaicin 8% Patches

    Research output: Contribution to journalComment/debateResearchpeer-review

  5. Treatment of Widespread Eosinophilic Cellulitis (Wells' Syndrome) with Benralizumab

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. Bariatric surgery and risk of new-onset inflammatory bowel disease: A nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The epidemiology and burden og psoriasis

    Research output: Book/ReportDoctoral thesis

View graph of relations

Early response to treatment with biologics might be important for the stability of psoriasis and long-term outcome. The aim of this study was therefore to assess whether risk of flares and drug survival are associated with disease activity in the first 6 months of treatment of psoriasis with biologics. Biologic-naïve patients from the Danish nationwide registry, DERMBIO, were grouped based on absolute Psoriasis Area and Severity Index (PASI) during the first 6 months of treatment, as: PASI = 0, PASI > 0-≤2, PASI > 2-≤ 4, and PASI > 4. Among 1,684 patients, 746 achieved PASI= 0, 485 PASI > 0-≤2, 246 PASI > 2-≤4, and 207 PASI > 4. Longer flare-free period and drug survival were observed for patients with lower PASI in the first 6 months of treatment (adjusted hazard ratios for flares (95% confidence interval) with PASI=  0 as reference: PASI > 0-≤2 (1.35 (1.11-1.72]), PASI > 2-≤ 4 (2.32 [1.80-2.99]), and PASI > 4 (2.38 [1.80-3.15])). In conclusion, a low PASI in the first 6 months of treatment with biologics in biologic-naïve patients with psoriasis was associated with a more stable disease course, lower risk of flares, and longer drug survival.

Original languageEnglish
Article numberadv00357
JournalActa Dermato-Venereologica
Volume101
Issue number1
Pages (from-to)1-7
Number of pages7
ISSN0001-5555
DOIs
Publication statusPublished - 4 Jan 2021

    Research areas

  • Biologics, Drug survival, Flares, PASI90PASI100, Psoriasis

ID: 61760793