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Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole

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BACKGROUND: Respiratory motion due to breathing during cardiac positron emission tomography (PET) results in spatial blurring and erroneous tracer quantification. Respiratory gating might represent a solution by dividing the PET coincidence dataset into smaller respiratory phase subsets. The aim of our study was to compare the resulting imaging quality by the use of a time-based respiratory gating system in two groups administered either adenosine or dipyridamole as the pharmacological stress agent.

METHODS AND RESULTS: Forty-eight patients were randomized to adenosine or dipyridamole cardiac stress 82RB-PET. Respiratory rates and depths were measured by a respiratory gating system in addition to registering actual respiratory rates. Patients undergoing adenosine stress showed a decrease in measured respiratory rate from initial to later scan phase measurements [12.4 (±5.7) vs 5.6 (±4.7) min-1, P < .001] and tended to have a lower frequency of successful respiratory gating compared to dipyridamole (47% vs 71%, P = .12). As a result, imaging quality was superior in the dipyridamole group compared to adenosine.

CONCLUSIONS: If respiratory gating is considered for use in cardiac PET, a dipyridamole stress protocol is recommended as it, compared to adenosine, causes a more uniform respiration and results in a higher frequency of successful respiratory gating and thereby superior imaging quality.

Original languageEnglish
JournalJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Volume24
Issue number6
Pages (from-to)1941-1949
Number of pages9
ISSN1071-3581
DOIs
Publication statusPublished - Dec 2017

    Research areas

  • Adenosine/pharmacology, Aged, Dipyridamole/pharmacology, Female, Humans, Male, Middle Aged, Motion, Positron-Emission Tomography/methods, Respiration/drug effects, Respiratory-Gated Imaging Techniques/methods

ID: 55064730