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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Research activity and capability in the European reference network MetabERN

Research output: Contribution to journalJournal articleResearchpeer-review

  1. An ontological foundation for ocular phenotypes and rare eye diseases

    Research output: Contribution to journalLetterResearchpeer-review

  2. Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Migalastat improves diarrhea in patients with Fabry disease: clinical-biomarker correlations from the phase 3 FACETS trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The complete European guidelines on phenylketonuria: diagnosis and treatment

    Research output: Contribution to journalReviewResearchpeer-review

  1. Impaired lipolysis in propionic acidemia: A new metabolic myopathy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increased risk of sudden death in untreated Primary Carnitine Deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cystic fibrosis newborn screening in Denmark: Experience from the first 2 years

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Danish expanded newborn screening is a successful preventive public health programme

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jean-Michel Heard
  • Cinzia Bellettato
  • Corine van Lingen
  • Maurizio Scarpa
  • MetabERN collaboration group
  • Allan Meldgaard Lund (Member of study group)
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BACKGROUND: MetabERN is one of the 24 European Reference Networks created according to the European Union directive 2011/24/EU on patient's rights in cross border healthcare. MetabERN associates 69 centres in 18 countries, which provide care for patients with Hereditary Metabolic Diseases, and have the mission to reinforce research and provide training for health professionals in this field. MetabERN performed a survey in December 2017 with the aim to produce an overview documenting research activities and potentials within the network. As the centres are multidisciplinary, separated questionnaires were sent to the clinical, university and laboratory teams. Answers were received from 52 out of the 69 centres of the network, covering 16 countries. A descriptive analysis of the information collected is presented.

RESULTS: The answers indicate a marked interest of the respondents for research, who expressed high motivation and commitment, and estimated that the conditions to do research in their institution were mostly satisfactory. They are active in research, which according to several indicators, is competitive and satisfies standards of excellence, as well as the education programs offered in the respondent's universities. Research in the centres is primarily performed in genetics, pathophysiology, and epidemiology, and focuses on issues related to diagnosis. Few respondents declared having activity in human and social sciences, including research on patient's quality of life, patient's awareness, or methods for social support. Infrastructures offering services for medical research were rarely known and used by respondents, including national and international biobanking platforms. In contrast, respondents often participate to patient registries, even beyond their specific field of interest.

CONCLUSIONS: Taken as a whole, these results provide an encouraging picture of the research capacities and activities in the MetabERN network, which, with respect to the number and representativeness of the investigated centres, gives a comprehensive picture of research on Hereditary Metabolic Diseases in Europe, as well as the priorities for future actions. Marginal activity in human and social sciences points out the limited multidisciplinary constitution of the responding teams with possible consequences on their current capability to participate to patient's empowerment programs and efficiently collaborate with patient's advocacy groups.

Original languageEnglish
JournalOrphanet Journal of Rare Diseases
Volume14
Issue number1
Pages (from-to)119
ISSN1750-1172
DOIs
Publication statusPublished - 2019

    Research areas

  • Europe, Humans, Interdisciplinary Research/methods, Quality of Life, Surveys and Questionnaires

ID: 58995194