Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Reproductive Hormones During Pubertal Transition in Girls with Transient Thelarche

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Metabolic and hormonal side effects of mitotane treatment for adrenocortical carcinoma: A retrospective study in 50 Danish patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Commentary on Winzeler et al 'Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia'

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Phenotypic and genotypic features of a large kindred with a germline AIP variant

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: A study from the Odense Child Cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Establishment of a novel human fetal adrenal culture model that supports de novo and manipulated steroidogenesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. CPMS-improving patient care in Europe via virtual case discussions

    Research output: Contribution to journalReviewpeer-review

View graph of relations

CONTEXT: Transient thelarche (TT), that is, the appearance, regression and subsequent reappearance of breast buds, is a frequent phenomenon, but little is known about pubertal transition in these girls.

OBJECTIVE: To describe pubertal progression, growth, genotypes, reproductive hormones and growth factors in girls with TT compared to those who do not present TT (non-TT).

DESIGN: Retrospective analysis of a longitudinal population-based study.

PATIENTS OR OTHER PARTICIPANTS: Girls (n = 508) of the Chilean Growth and Obesity cohort.

MEASUREMENTS: Pubertal progression, reproductive hormones, follicle stimulating hormone (FSH) beta subunit/FSH receptor gene single nucleotide polymorphisms and growth.

RESULTS: Thirty-seven girls (7.3%) were presented TT. These girls entered puberty by pubarche more frequently (51%) than girls with normal progression (non-TT; n = 471; 23%, P = .005). Girls with TT who were under 8 years old had lower androgens, anti-Müllerian hormone (AMH), luteinizing hormone (LH) and oestradiol (all P < .05) than older girls with TT. At the time of Tanner breast stage 2 (B2), girls with TT had higher androgens, LH, FSH, IGF1, LH, insulin and oestradiol (P < .01) than at the time of TT. TT girls were older at B2 (10.3 ± 1.1 vs. 9.2 ± 1.2 years, P < .001) and menarche (12.3 ± 0.8 vs. 12.0 ± 1.0 years, P = .040) than their counterparts (non-TT). No differences in anthropometric variables or FSHB/FSHR genotypes were detected.

CONCLUSION: Transient thelarche is a frequent phenomenon that does not appear to be mediated by hypothalamic-pituitary-gonadal axis activation or by adiposity. Hormonal differences between earlier TT and later TT suggest that their mechanisms are different.

Original languageEnglish
JournalClinical Endocrinology
Volume93
Issue number3
Pages (from-to)296-304
Number of pages9
ISSN0300-0664
DOIs
Publication statusPublished - 1 Sep 2020

Bibliographical note

© 2020 John Wiley & Sons Ltd.

    Research areas

  • androgens, environmental disruptors, puberty, transient thelarche

ID: 59885325