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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Reproductive endocrinology of vitamin D

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  1. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

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  2. Characterisation and localisation of the endocannabinoid system components in the adult human testis

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  3. Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome

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  4. Characterization of Human Adrenal Steroidogenesis during Fetal Development

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  5. Populations, decreasing fertility, and reproductive health

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Vitamin D is a versatile hormone with several functions beyond its well-established role in maintenance of skeletal health and calcium homeostasis. The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues. The reproductive organs are therefore responsive to and able to metabolize vitamin D locally. The exact role remains to be clarified but several studies have suggested a link between vitamin D and production/release of reproductive hormones into circulation, which will be the main focus of this review. Current evidence is primarily based on small human association studies and rodent models. This highlights the need for randomized clinical trials, but also functional animal and human in vitro studies, and larger, prospective cohort studies are warranted. Given the high number of men and women suffering from reproductive problems and abnormal endocrinology research addressing the role of vitamin D in reproductive endocrinology is of clinical importance.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume453
Pages (from-to)103-112
ISSN0303-7207
DOIs
Publication statusPublished - 15 Sep 2017

    Research areas

  • Journal Article

ID: 50151076