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Report from the CVOT Summit 2021: new cardiovascular, renal, and glycemic outcomes

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  1. Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmö Preventive Project

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  2. Effects of sacubitril/valsartan on glycemia in patients with diabetes and heart failure: the PARAGON-HF and PARADIGM-HF trials

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  3. Temporal patterns of multi-morbidity in 570157 ischemic heart disease patients: a nationwide cohort study

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  1. Enterohepatic, Gluco-metabolic, and Gut Microbial Characterization of Individuals With Bile Acid Malabsorption

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  2. Blood Pressure and Cardiorenal Outcomes With Finerenone in Chronic Kidney Disease in Type 2 Diabetes

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  3. Diagnostic and prognostic value of the electrocardiogram in stable outpatients with type 2 diabetes

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  • Oliver Schnell
  • Tadej Battelino
  • Richard Bergenstal
  • Matthias Blüher
  • Michael Böhm
  • Frank Brosius
  • Richard D. Carr
  • Antonio Ceriello
  • Thomas Forst
  • Francesco Giorgino
  • Bruno Guerci
  • Hiddo J.L. Heerspink
  • Baruch Itzhak
  • Linong Ji
  • Mikhail Kosiborod
  • Nebojša Lalić
  • Michael Lehrke
  • Nikolaus Marx
  • Michael Nauck
  • Helena W. Rodbard
  • Giuseppe M.C. Rosano
  • Peter Rossing
  • Lars Rydén
  • Francesca Santilli
  • Petra Maria Schumm-Draeger
  • Per Olav Vandvik
  • Tina Vilsbøll
  • Christoph Wanner
  • Carol Wysham
  • Eberhard Standl
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The 7th Cardiovascular Outcome Trial (CVOT) Summit on Cardiovascular, Renal, and Glycemic Outcomes, was held virtually on November 18–19, 2021. Pursuing the tradition of the previous summits, this reference congress served as a platform for in-depth discussion and exchange on recently completed CVOTs. This year’s focus was placed on the outcomes of EMPEROR-Preserved, FIGARO-DKD, AMPLITUDE-O, SURPASS 1–5, and STEP 1–5. Trial implications for diabetes and obesity management and the impact on new treatment algorithms were highlighted for endocrinologists, diabetologists, cardiologists, nephrologists, and general practitioners. Discussions evolved from outcome trials using SGLT2 inhibitors as therapy for heart failure, to CVOTs with nonsteroidal mineralocorticoid receptor antagonists and GLP-1 receptor agonists. Furthermore, trials for glycemic and overweight/obesity management, challenges in diabetes management in COVID-19, and novel guidelines and treatment strategies were discussed. Trial registration The 8th Cardiovascular Outcome Trial Summit will be held virtually on November 10–11, 2022 (http://www.cvot.org).

Original languageEnglish
Article number50
JournalCardiovascular Diabetology
Volume21
Issue number1
Pages (from-to)50
ISSN1475-2840
DOIs
Publication statusPublished - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

    Research areas

  • Blood Glucose, COVID-19, Cardiovascular Diseases/drug therapy, Clinical Trials as Topic, Diabetes Mellitus/drug therapy, Humans, Hypoglycemic Agents/therapeutic use, Sodium-Glucose Transporter 2 Inhibitors/therapeutic use, Treatment Outcome

ID: 79243377