Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

Evangelos Vassos, Stacy Steinberg, Sven Cichon, Gerome Breen, Engilbert Sigurdsson, Ole A Andreassen, Srdjan Djurovic, Gunnar Morken, Maria Grigoroiu-Serbanescu, Carmen C Diaconu, Piotr M Czerski, Joanna Hauser, Gulja Babadjanova, Lilia I Abramova, Thomas W Mühleisen, Markus M Nöthen, Marcella Rietschel, Peter McGuffin, David St Clair, Omar GustafssonIngrid Melle, Olli P H Pietiläinen, Mirella Ruggeri, Sarah Tosato, Thomas Werge, Roel A Ophoff, Dan Rujescu, Anders Børglum, Ole Mors, Preben Bo Mortensen, Ditte Demontis, Mads Vilhelm Hollegaard, Ruud van Winkel, Gunter Kenis, Marc De Hert, János M Réthelyi, István Bitter, I Alex Rubino, Vera Golimbet, Lambertus A Kiemeney, Leonard H van den Berg, Barbara Franke, Erik G Jönsson, Anne Farmer, Hreinn Stefansson, Kari Stefansson, David A Collier, GROUP Consortium

15 Citations (Scopus)

Abstract

Common genetic polymorphisms at chromosome 3p21.1, including rs2251219 in polybromo 1 (PBRM1), have been implicated in susceptibility to bipolar affective disorder (BP) through genome-wide association studies. Subsequent studies have suggested that this is also a risk locus for other psychiatric phenotypes, including major depression and schizophrenia.
Original languageEnglish
JournalBiological Psychiatry
Volume72
Issue number8
Pages (from-to)645-50
Number of pages6
ISSN0006-3223
DOIs
Publication statusPublished - 2012

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