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Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats

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  3. Bone metabolism in obesity: changes related to severe overweight and dietary weight reduction.

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  4. Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

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  3. New insights into the aspects of pulmonary diffusing capacity in Fontan patients

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  4. Clopidogrel in infants with systemic-to-pulmonary-artery shunts

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Previous in vitro findings suggest the involvement of interleukin 1 (IL-1) in the pathogenesis of insulin-dependent diabetes mellitus. The aims of the present study were to investigate the effects of single or repeated ip injections of recombinant IL-1 beta on blood glucose and glucose tolerance in vivo. Normal Wistar Kyoto rats were injected ip with a single injection of 4 micrograms/kg of the mature form of recombinant IL-1 beta (amino acids 117-269) or once daily on 5 consecutive days. Control rats were given vehicle and were fed ad libitum or pair-fed together with the rIL-1 beta treated rats. An ip glucose tolerance test (0.2 g D-glucose/100 g) was performed 2 h after injection of rIL-1 beta. A single injection of rIL-1 beta caused a mild depression in blood glucose and an improved glucose tolerance. Multiple injections of rIL-1 beta induced a diminished weight gain, a 24-28% reduction in food intake, a lasting mild depression of blood glucose (7 days) and a transiently impaired glucose tolerance on day 5. We conclude that systemic IL-1 should be considered an important regulator of glucose homeostasis in vivo.

Original languageEnglish
JournalActa Endocrinologica (Copenh)
Volume124
Issue number4
Pages (from-to)470-8
Number of pages9
ISSN0001-5598
Publication statusPublished - Apr 1991

    Research areas

  • Animals, Blood Glucose, Body Temperature, Body Weight, Diabetes Mellitus, Experimental, Dose-Response Relationship, Drug, Eating, Glucose, Glucose Tolerance Test, Homeostasis, Injections, Intraperitoneal, Interleukin-1, Iodine Radioisotopes, Male, Rats, Rats, Inbred WKY, Recombinant Proteins

ID: 43640734