Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S Sutton; Amy L Walz; Alissa Groenendijk; Andrew J Murphy; Luke Pater; Geert O Janssens; Jack Brzezinski; Elizabeth A Mullen; Filippo Spreafico; Jan Godzinski; Justine van der Beek; Marc Hwa Wijnen; Marry M van den Heuvel-Eibrink; Max Pachl; Norbert Graf; Peter F Ehrlich; Rhoikos Furtwangler; Jesper Brok; James Geller

doi:10.1002/pbc.31790

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Kathryn S Sutton^*, Amy L Walz, Alissa Groenendijk, Andrew J Murphy, Luke Pater, Geert O Janssens, Jack Brzezinski, Elizabeth A Mullen, Filippo Spreafico, Jan Godzinski, Justine van der Beek, Marc Hwa Wijnen, Marry M van den Heuvel-Eibrink, Max Pachl, Norbert Graf, Peter F Ehrlich, Rhoikos Furtwangler, Jesper Brok, James Geller

^*Corresponding author for this work

Department of Paediatrics and Adolescent Medicine

4 Citations (Scopus)

Abstract

Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

Original language	English
Article number	e31790
Journal	Pediatric Blood & Cancer
Volume	72
Issue number	8
Pages (from-to)	e31790
ISSN	1545-5009
DOIs	https://doi.org/10.1002/pbc.31790
Publication status	Published - Aug 2025

Keywords

Child
Humans
Kidney Neoplasms/therapy
Neoplasm Recurrence, Local/therapy
Wilms Tumor/therapy
renal
tumors
solid
Wilms tumor

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Sutton, K. S., Walz, A. L., Groenendijk, A., Murphy, A. J., Pater, L., Janssens, G. O., Brzezinski, J., Mullen, E. A., Spreafico, F., Godzinski, J., van der Beek, J., Hwa Wijnen, M., van den Heuvel-Eibrink, M. M., Pachl, M., Graf, N., Ehrlich, P. F., Furtwangler, R., Brok, J., & Geller, J. (2025). Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives. Pediatric Blood & Cancer, 72(8), e31790. Article e31790. https://doi.org/10.1002/pbc.31790

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives. / Sutton, Kathryn S; Walz, Amy L; Groenendijk, Alissa et al.
In: Pediatric Blood & Cancer, Vol. 72, No. 8, e31790, 08.2025, p. e31790.

Research output: Contribution to journal › Journal article › Research › peer-review

Sutton, KS, Walz, AL, Groenendijk, A, Murphy, AJ, Pater, L, Janssens, GO, Brzezinski, J, Mullen, EA, Spreafico, F, Godzinski, J, van der Beek, J, Hwa Wijnen, M, van den Heuvel-Eibrink, MM, Pachl, M, Graf, N, Ehrlich, PF, Furtwangler, R, Brok, J & Geller, J 2025, 'Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives', Pediatric Blood & Cancer, vol. 72, no. 8, e31790, pp. e31790. https://doi.org/10.1002/pbc.31790

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title = "Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives",

abstract = "Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.",

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AU - Murphy, Andrew J

AU - Pater, Luke

AU - Janssens, Geert O

AU - Brzezinski, Jack

AU - Mullen, Elizabeth A

AU - Spreafico, Filippo

AU - Godzinski, Jan

AU - van der Beek, Justine

AU - Hwa Wijnen, Marc

AU - van den Heuvel-Eibrink, Marry M

AU - Pachl, Max

AU - Graf, Norbert

AU - Ehrlich, Peter F

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AU - Geller, James

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AB - Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children's Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

KW - Child

KW - Humans

KW - Kidney Neoplasms/therapy

KW - Neoplasm Recurrence, Local/therapy

KW - Wilms Tumor/therapy

KW - renal

KW - tumors

KW - solid

KW - Wilms tumor

UR - https://www.scopus.com/pages/publications/105005410450

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DO - 10.1002/pbc.31790

M3 - Journal article

C2 - 40369656

SN - 1545-5009

VL - 72

SP - e31790

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

IS - 8

M1 - e31790

ER -

Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children's Oncology Group and International Society of Paediatric Oncology Perspectives

Abstract

Keywords

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