Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Reliability of early and late testing for suspected perioperative hypersensitivity

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Airway hyperresponsiveness to inhaled mannitol identifies a cluster of non-eosinophilic asthma patients with high symptom burden

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The passively sensitized mast cell activation test is a reliable diagnostic for chlorhexidine allergy

    Research output: Contribution to journalLetterResearchpeer-review

  3. Mast Cell Activation During Suspected Perioperative Hypersensitivity: A Need for Paired Samples Analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis

    Research output: Contribution to journalReviewResearchpeer-review

  5. Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Optimizing investigation of suspected allergy to polyethylene glycols

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Facial contact dermatitis caused by cosmetic-relevant allergens

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hypersensitivity to vitamins with a focus on immediate-type reactions: Food or drug allergy?

    Research output: Contribution to journalReviewResearchpeer-review

  4. The passively sensitized mast cell activation test is a reliable diagnostic for chlorhexidine allergy

    Research output: Contribution to journalLetterResearchpeer-review

  5. Anaphylaxis to the first dose of mRNA SARS-CoV-2 vaccines: Don't give up on the second dose!

    Research output: Contribution to journalLetterResearchpeer-review

  • Marie-Line M Van der Poorten
  • Walschot Mark
  • Margaretha Faber
  • Jessy Elst
  • Athina L Van Gasse
  • Leander De Puysseleyr
  • Mertens Christel M
  • Margo M Hagendorens
  • Lene H Garvey
  • Vito Sabato
  • Didier G Ebo
View graph of relations

BACKGROUND: The optimal timing of diagnostic testing for perioperative hypersensitivity (POH) remains unknown. It has been recommended that investigation is best carried out at least 4 to 6 weeks after the event. On the other hand, guidelines discourage the use of in vitro tests later than 3 years after the index reaction.

OBJECTIVE: This retrospective study aimed to assess the reliability of early and late skin tests (STs). It also attempted to verify whether discouraging late ex vivo and in vitro tests is substantiated.

METHODS: For the first aim, patients were stratified over three epochs: an early timing group, with investigations performed within 6 weeks; a recommended timing group, with tests performed between 6 weeks and 6 months; and a late timing group, tested later than 6 months after the event. For the second study purpose, we studied the reliability of specific IgE quantification and basophil activation test rocuronium within 6 weeks and after 3 years in patients who experienced an ST-proven POH to rocuronium.

RESULTS: A total of 677 patients were included. Based on a positive ST result, a causative agent was found in 74.2% of the early timing group, 62.6% of the recommended timing group, and 50% of the late timing group. A positive specific IgE for rocuronium or morphine was found in 80% of patients tested within 6 weeks, 63% of patients tested between 6 weeks and 3 years, and 50% of patients tested more than 3 years after the event. A positive basophil activation test was found in 83.3%, 51%, and 20%, respectively, of patients.

CONCLUSIONS: Our data confirm that evaluation of drug allergy for suspected POH can be performed before 6 weeks after the event, and there is no maximal upper time limit disclosing ex vivo and in vitro testing.

Original languageEnglish
JournalThe journal of allergy and clinical immunology. In practice
ISSN2213-2198
DOIs
Publication statusE-pub ahead of print - 9 Nov 2021

Bibliographical note

Copyright © 2021. Published by Elsevier Inc.

    Research areas

  • Anaphylaxis, Anesthetic reactions, Drug reactions, In vitro diagnostics, Perioperative hypersensitivity, Skin testing, sIgE quantification

ID: 69212140