Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects

Paul J W H Kappelle; Gilles Lambert; Björn Dahlbäck; Lars Bo Nielsen; Robin P F Dullaart

doi:10.1016/j.atherosclerosis.2010.10.041

Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects

Paul J W H Kappelle
, Gilles Lambert
, Björn Dahlbäck
, Lars Bo Nielsen
, Robin P F Dullaart

Department of Clinical Biochemistry

12 Citations (Scopus)

Abstract

Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.

Original language	English
Journal	Atherosclerosis
Volume	214
Issue number	2
Pages (from-to)	492-4
Number of pages	3
ISSN	0021-9150
DOIs	https://doi.org/10.1016/j.atherosclerosis.2010.10.041
Publication status	Published - 2011

Keywords

Adiposity
Aged
Apolipoproteins
Apolipoproteins B
Biological Markers
Body Mass Index
Cholesterol
Cholesterol, LDL
Enzyme-Linked Immunosorbent Assay
Humans
Lipocalins
Middle Aged
Netherlands
Obesity
Overweight
Regression Analysis
Serine Endopeptidases

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10.1016/j.atherosclerosis.2010.10.041

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@article{7539e88ec2be431cbcd5a01aa8f037b3,

title = "Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects",

abstract = "Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.",

keywords = "Adiposity, Aged, Apolipoproteins, Apolipoproteins B, Biological Markers, Body Mass Index, Cholesterol, Cholesterol, LDL, Enzyme-Linked Immunosorbent Assay, Humans, Lipocalins, Middle Aged, Netherlands, Obesity, Overweight, Regression Analysis, Serine Endopeptidases",

author = "Kappelle, \{Paul J W H\} and Gilles Lambert and Bj{\"o}rn Dahlb{\"a}ck and Nielsen, \{Lars Bo\} and Dullaart, \{Robin P F\}",

note = "Copyright {\textcopyright} 2010. Published by Elsevier Ireland Ltd.",

year = "2011",

doi = "10.1016/j.atherosclerosis.2010.10.041",

language = "English",

volume = "214",

pages = "492--4",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects

AU - Kappelle, Paul J W H

AU - Lambert, Gilles

AU - Dahlbäck, Björn

AU - Nielsen, Lars Bo

AU - Dullaart, Robin P F

PY - 2011

Y1 - 2011

N2 - Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.

AB - Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.

KW - Adiposity

KW - Aged

KW - Apolipoproteins

KW - Apolipoproteins B

KW - Biological Markers

KW - Body Mass Index

KW - Cholesterol

KW - Cholesterol, LDL

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Lipocalins

KW - Middle Aged

KW - Netherlands

KW - Obesity

KW - Overweight

KW - Regression Analysis

KW - Serine Endopeptidases

U2 - 10.1016/j.atherosclerosis.2010.10.041

DO - 10.1016/j.atherosclerosis.2010.10.041

M3 - Journal article

C2 - 21122852

SN - 0021-9150

VL - 214

SP - 492

EP - 494

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects

Abstract

Keywords

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