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Relation between plasma and brain lipids

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  1. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

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  2. Remnant lipoproteins

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  3. Using human genetics to predict the effects and side-effects of drugs

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  4. Novel genes in LDL metabolism--a comprehensive overview

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  5. Apolipoprotein M in lipid metabolism and cardiometabolic diseases

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  1. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

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  2. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

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  3. Impact of glucose on risk of dementia: Mendelian randomisation studies in 115,875 individuals

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  4. Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals

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PURPOSE OF REVIEW: This article evaluates recent experimental and human evidence regarding the involvement of lipids, lipoproteins, and apolipoproteins in neurodegenerative diseases, and reviews the current literature of the effects of cholesterol-lowering treatment on cognition.

RECENT FINDINGS: Plasma levels of traditional lipids and lipoproteins are not consistently associated with risk of dementia even though low plasma levels of apolipoprotein E, through unknown mechanisms, robustly predict future dementia. Experimental evidence suggests neuroprotective roles of several brain and cerebrospinal fluid apolipoproteins. Whether plasma levels of apolipoprotein E, or any other apolipoprotein with possible central nervous system and/or blood-brain barrier functions (apolipoproteins J, A-I, A-II, A-IV, D, C-I, and C-III) may become accessible biomarker components that improve risk prediction for dementia together with genetic risk variants and cardiovascular risk factors remains to be determined.

SUMMARY: Apolipoproteins with well established functions in peripheral lipid metabolism may play important roles for brain vascular health and Alzheimer's disease pathophysiology. Experimental work on lipids, lipoproteins, and apolipoproteins in the central nervous system together with robust prospective human studies will help to substantiate the drug target potential of these lipid components.

Original languageEnglish
JournalCurrent Opinion in Lipidology
Volume27
Issue number3
Pages (from-to)225-32
Number of pages8
ISSN0957-9672
DOIs
Publication statusPublished - Jun 2016

    Research areas

  • Journal Article

ID: 49458767