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Relation between plasma and brain lipids

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  1. Impact of metabolic dysfunction on cognition in humans

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  2. Lipoprotein(a): is it more, less or equal to LDL as a causal factor for cardiovascular disease and mortality?

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  3. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

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  4. Remnant lipoproteins

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  5. Using human genetics to predict the effects and side-effects of drugs

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  1. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

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  2. Association of Low Plasma Transthyretin Concentration With Risk of Heart Failure in the General Population

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  3. Impact of metabolic dysfunction on cognition in humans

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PURPOSE OF REVIEW: This article evaluates recent experimental and human evidence regarding the involvement of lipids, lipoproteins, and apolipoproteins in neurodegenerative diseases, and reviews the current literature of the effects of cholesterol-lowering treatment on cognition.

RECENT FINDINGS: Plasma levels of traditional lipids and lipoproteins are not consistently associated with risk of dementia even though low plasma levels of apolipoprotein E, through unknown mechanisms, robustly predict future dementia. Experimental evidence suggests neuroprotective roles of several brain and cerebrospinal fluid apolipoproteins. Whether plasma levels of apolipoprotein E, or any other apolipoprotein with possible central nervous system and/or blood-brain barrier functions (apolipoproteins J, A-I, A-II, A-IV, D, C-I, and C-III) may become accessible biomarker components that improve risk prediction for dementia together with genetic risk variants and cardiovascular risk factors remains to be determined.

SUMMARY: Apolipoproteins with well established functions in peripheral lipid metabolism may play important roles for brain vascular health and Alzheimer's disease pathophysiology. Experimental work on lipids, lipoproteins, and apolipoproteins in the central nervous system together with robust prospective human studies will help to substantiate the drug target potential of these lipid components.

Original languageEnglish
JournalCurrent Opinion in Lipidology
Volume27
Issue number3
Pages (from-to)225-32
Number of pages8
ISSN0957-9672
DOIs
Publication statusPublished - Jun 2016

    Research areas

  • Journal Article

ID: 49458767