Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Relation between invasive hemodynamics and measured glomerular filtration rate by 51Cr-EDTA clearance in advanced heart failure

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Platelet function in lung cancer patients undergoing lobectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Platelet increment is not associated with endothelial damage in haematological patients: a prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Change in HbA1c concentration as decision parameter for frequency of HbA1c measurement

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Outcome after heart-lung or lung transplantation in patients with Eisenmenger syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Performance of Prognostic Risk Scores in Heart Failure Patients: Do Sex Differences Exist?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Socioeconomic position and one-year mortality risk among patients with heart failure: A nationwide register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid ( 51 Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP). We retrospectively studied 242 patients (mean age 50 ± 13 years) referred for evaluation for heart transplantation or implantation of a left ventricular assist device with a left ventricular ejection fraction < 45% on optimal medical therapy, who underwent right heart catheterization (RHC) and measurement of 51 Cr-EDTA clearance. Mean mGFR was 63 ± 21 mL/min/1.73 m 2 , CI was 2.3 ± 0.7 L/min/m 2 , PCWP was 21 ± 9 mmHg, and CVP was 10.3 ± 5.2 mmHg. Univariate analysis demonstrated a significant correlation between mGFR and CI (r 2 = 0.030, p =.007) and CVP (r 2 = 0.017, p =.049) but not between mGFR and MAP or PCWP. In multivariate analyses, none of the hemodynamic variables remained significantly associated with mGFR. While CVP and CI were correlated with mGFR in univariate analysis the results of analyses adjusted for multiple covariates suggest that hemodynamics are only correlated to renal function in advanced HF to a modest degree challenging the hypothesis that renal dysfunction in HF mainly is a consequence of renal congestion.

Original languageEnglish
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume79
Issue number3
Pages (from-to)194-201
Number of pages8
ISSN0036-5513
DOIs
Publication statusPublished - 3 Apr 2019

    Research areas

  • Heart failure, hemodynamics, renal dysfunction, right heart catheterization

ID: 57662299