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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Relapse of Neonatal Escherichia coli Meningitis: Did We Miss Something at First?

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DOI

  1. Cost of Illness in Young Children: A Prospective Birth Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Season of Birth Impacts the Neonatal Nasopharyngeal Microbiota

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  3. Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood

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  1. PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cost of Illness in Young Children: A Prospective Birth Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Paediatric hepatitis B and hepatitis C virus infections: an observational study of a Danish cohort

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  4. Tidligt skift fra intravenøs fra intravenøs til antibiotikabehandling

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Relapse of neonatal meningitis is most commonly caused by Escherichia coli. Management to prevent relapse varies and evidence is limited. We present four cases of relapsing neonatal E. coli meningitis in Denmark in 2016-2017 and review the current literature on this subject. During the primary episodes, our patients received cephalosporin for 3 weeks and gentamicin for the first 3 days. The only identified risk factor was delayed CSF sterilization in three of four cases and no repeated lumbar puncture. Relapse occurred after 2-28 days; one case with ventriculitis and one with empyema. Relapses were treated for 6-14 weeks with monotherapy. No children had an underlying disease predisposing to E. coli meningitis. There is generally a trend towards reducing invasive procedures, e.g., lumbar puncture and the length of intravenous antibiotics in pediatric infectious diseases, but our cases highlight a condition where the opposite might be needed.

Original languageEnglish
JournalChildren (Basel, Switzerland)
Volume8
Issue number2
ISSN2227-9067
DOIs
Publication statusPublished - 10 Feb 2021

ID: 62244201